Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin

Abstract We describe a 91-year-old woman who suffered from fungal keratitis after corneal transplantation. The causative organism was identified as Wickerhamomyces anomalus (formerly Pichia anomala or Hansenula anomala ) on the basis of morphological characteristics and the sequence of the internal...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2015-02, Vol.21 (2), p.141-143
Main Authors: Kamoshita, Mamoru, Matsumoto, Yukihiro, Nishimura, Kazuko, Katono, Yasuhiro, Murata, Mitsuru, Ozawa, Yoko, Shimmura, Shigeto, Tsubota, Kazuo
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antifungal Agents - therapeutic use
Echinocandins - therapeutic use
Eye Infections, Fungal - drug therapy
Eye Infections, Fungal - microbiology
Eye Infections, Fungal - pathology
Female
Fungal keratitis
Hansenula anomala
Hematology, Oncology and Palliative Medicine
Humans
Keratitis - drug therapy
Keratitis - microbiology
Keratitis - pathology
Lipopeptides - therapeutic use
Micafungin
Pichia anomala
Saccharomycetales - isolation & purification
Wickerhamomyces anomalus
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Summary:Abstract We describe a 91-year-old woman who suffered from fungal keratitis after corneal transplantation. The causative organism was identified as Wickerhamomyces anomalus (formerly Pichia anomala or Hansenula anomala ) on the basis of morphological characteristics and the sequence of the internal transcribed spacer region of the ribosomal RNA gene. The patient was successfully treated with topical micafungin (MCFG) only. We present the first report of a case of W. anomalus fungal keratitis that responded to topical treatment with the antifungal MCFG.
ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2014.08.019