Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride

Previous reports including genome-wide association studies (GWASs) have described associations of serum lipids with genomic variations. In the present study, we examined the association of ∼2.5 million single-nucleotide polymorphisms (SNPs) from 3041 Japanese healthy volunteers obtained from the Jap...

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Bibliographic Details
Published in:Journal of human genetics 2016-05, Vol.61 (5), p.427-433
Main Authors: Kurano, Makoto, Tsukamoto, Kazuhisa, Kamitsuji, Shigeo, Kamatani, Naoyuki, Hara, Masumi, Ishikawa, Toshio, Kim, Bong-Jo, Moon, Sanghoon, Jin Kim, Young, Teramoto, Tamio
Format: Article
Language:English
Subjects:
Female
Genome-Wide Association Study
Genotype
Healthy Volunteers
Humans
Lipids - blood
Male
Phenotype
Polymorphism, Single Nucleotide
Population Surveillance
Subtilisins - genetics
Triglycerides - blood
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Summary:Previous reports including genome-wide association studies (GWASs) have described associations of serum lipids with genomic variations. In the present study, we examined the association of ∼2.5 million single-nucleotide polymorphisms (SNPs) from 3041 Japanese healthy volunteers obtained from the Japan Pharmacogenomics Data Science Consortium (JPDSC) database with serum lipids. We confirmed the previously reported associations of 14 SNPs in 5 regions for low-density lipoprotein (LDL) cholesterol, 23 SNPs in 12 regions for high-density lipoprotein (HDL) cholesterol, 16 SNPs in 6 regions for triglyceride and 5 SNPs in 1 region for phospholipid. Furthermore, we identified 16 possible novel candidate genes associated with LDL cholesterol, HDL cholesterol or triglycerides, where SNPs had P-values of
ISSN:1434-5161
1435-232X
DOI:10.1038/jhg.2015.170