Setting a standard for the initiation of steroid therapy in refractory or severe Mycoplasma pneumoniae pneumonia in adolescents and adults

Abstract Serum interleukin (IL)-18 level was thought to be a useful as a predictor of refractory or severe Mycoplasma pneumoniae pneumonia, and steroid administration is reported to be effective in this situation. The serum levels of IL-18 correlated significantly with those of lactate dehydrogenase...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2015-03, Vol.21 (3), p.153-160
Main Authors: Miyashita, Naoyuki, Kawai, Yasuhiro, Inamura, Norikazu, Tanaka, Takaaki, Akaike, Hiroto, Teranishi, Hideto, Wakabayashi, Tokio, Nakano, Takashi, Ouchi, Kazunobu, Okimoto, Niro
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biomarkers - blood
Female
Hematology, Oncology and Palliative Medicine
Humans
Interleukin 18
Interleukin-18 - blood
L-Lactate Dehydrogenase - blood
Lactate dehydrogenase
Male
Middle Aged
Mycoplasma pneumoniae
Mycoplasma pneumoniae - pathogenicity
Pneumonia, Mycoplasma - blood
Pneumonia, Mycoplasma - drug therapy
Refractory pneumonia
Severe pneumonia
Steroid therapy
Steroids - standards
Steroids - therapeutic use
Young Adult
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Summary:Abstract Serum interleukin (IL)-18 level was thought to be a useful as a predictor of refractory or severe Mycoplasma pneumoniae pneumonia, and steroid administration is reported to be effective in this situation. The serum levels of IL-18 correlated significantly with those of lactate dehydrogenase (LDH). The purpose of this study was to set a standard for the initiation of steroid therapy in M. pneumoniae pneumonia using a simple serum marker. We analyzed 41 adolescent and adult patients with refractory or severe M. pneumoniae pneumonia who received steroid therapy, and compared them with 108 patients with M. pneumoniae pneumonia who responded to treatment promptly (control group). Serum LDH levels were significantly higher in the refractory and severe group than in the control group at the initiation of steroid therapy (723 vs 210 IU/L, respectively; p  
ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2014.10.008