Platelet-Activating Factor Receptor (PAFR) plays a crucial role in experimental global cerebral ischemia and reperfusion

• Published in: Brain research bulletin 2016-06, Vol.124, p.55-61
• Main Authors: de Brito Toscano, Eliana Cristina, Costa Silva, Bruno, Constaza Gómez Victoria, Edna, de Souza Cardoso, Ana Clara, de Miranda, Aline Silva, Sugimoto, Michelle Adriane, Sousa, Lirlândia Pires, de Carvalho, Bárbara Andrade, Kangussu, Lucas Miranda, da Silva, Daniele Gonçalves, Rodrigues, Flávia Guimarães, da Silva Barcelos, Lucíola, Vasconcelos, Anilton César, Amaral, Flávio Almeida, Teixeira, Mauro Martins, Teixeira, Antônio Lúcio, Rachid, Milene Alvarenga
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis; Blood-Brain Barrier - physiopathology; Brain; Brain Infarction - etiology; Caspase 3 - metabolism; Cytokines; Cytokines - metabolism; Disease Models, Animal; Gene Expression Regulation - genetics; Inflammation; Ischemia; Ischemic Attack, Transient - complications; Ischemic Attack, Transient - metabolism; Ischemic Attack, Transient - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nervous System Diseases - etiology; Neurology; PAFR; Platelet Membrane Glycoproteins - genetics; Platelet Membrane Glycoproteins - metabolism; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Reperfusion; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Statistics, Nonparametric
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2016.03.022

Highlights • PAFR plays a crucial role in experimental brain ischemia and reperfusion. • PAFR deficiency improved neurological deficits and promoted neuroprotection. • PAFR deficiency controls pro-inflammatory cytokines in the ischemic brain.