Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population

Highlights • 772 patients and 775 controls were compared for IL-18 level and its −607A/C polymorphism. • No significant differences in the allele and genotype frequencies between the patients and controls. • Increased IL-18 and it polymorphism were associated with the PANSS total and G subscale scor...

Full description

Saved in:
Bibliographic Details
Published in:Psychoneuroendocrinology 2016-06, Vol.68, p.140-147
Main Authors: Zhang, Xiang Yang, Tan, Yun-Long, Chen, Da-Chun, Tan, Shu-Ping, Malouta, Michelle, Bernard, Jared D, Combs, Jessica L, Bhatti, Sarai, Davis, Michael C, Kosten, Thomas R, Soares, Jair C
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Case-Control Studies
China
Cytokines
Endocrinology & Metabolism
Ethnic Groups - genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interleukin
Interleukin-18 - blood
Interleukin-18 - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Psychiatric Status Rating Scales
Psychiatry
Schizophrenia
Schizophrenia - blood
Schizophrenia - genetics
Symptom
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • 772 patients and 775 controls were compared for IL-18 level and its −607A/C polymorphism. • No significant differences in the allele and genotype frequencies between the patients and controls. • Increased IL-18 and it polymorphism were associated with the PANSS total and G subscale scores. • Association of IL-18 with clinical symptoms was present only among patients carrying the C allele.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.03.002