Physical and emotional well-being of survivors of childhood and young adult allo-SCT - A Danish national cohort study

The aim of this investigation was to examine, within a population‐based study of a national cohort comprising Danish survivors of allo‐SCT (n = 148), the long‐term effects of allo‐SCT in children and young adults. Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric transplantation 2016-08, Vol.20 (5), p.697-706
Main Authors: Jensen, Josef Nathan, Gøtzsche, Frederik, Heilmann, Carsten, Sengeløv, Henrik, Adamsen, Lis, Christensen, Karl Bang, Larsen, Hanne Bækgaard
Format: Article
Language:English
Subjects:
Adolescent
adolescents
Adult
Anxiety - diagnosis
Anxiety - epidemiology
Anxiety - etiology
Child
Child, Preschool
Denmark - epidemiology
depression
Depression - diagnosis
Depression - epidemiology
Depression - etiology
Female
Follow-Up Studies
graft-vs.-host disease
Health Status
Health Status Indicators
hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - psychology
Humans
Infant
Infant, Newborn
Male
Mental Health
pediatric
Quality of Life - psychology
quality-of-life
Survivors - psychology
Transplantation, Homologous
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this investigation was to examine, within a population‐based study of a national cohort comprising Danish survivors of allo‐SCT (n = 148), the long‐term effects of allo‐SCT in children and young adults. Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the HADS. Allo‐SCT‐related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used. Factors negatively influencing the SF‐36 subscales included female gender; TBI; stem cells derived from PB; older age at time of questioning; and living alone. Factors significantly (p < 0.05) influencing HADS were transplantation with stem cells derived from PB and being underweight at time of questioning (median values were within normal range). Overall scores of allo‐SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life (
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12713