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Physical and emotional well-being of survivors of childhood and young adult allo-SCT - A Danish national cohort study
The aim of this investigation was to examine, within a population‐based study of a national cohort comprising Danish survivors of allo‐SCT (n = 148), the long‐term effects of allo‐SCT in children and young adults. Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the...
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| Published in: | Pediatric transplantation 2016-08, Vol.20 (5), p.697-706 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c4703-deaab1a0f1fc41c6a1f241f58291e949ccfb3323d889f46dac054894bca33b5c3 |
| container_end_page | 706 |
| container_issue | 5 |
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| container_title | Pediatric transplantation |
| container_volume | 20 |
| creator | Jensen, Josef Nathan Gøtzsche, Frederik Heilmann, Carsten Sengeløv, Henrik Adamsen, Lis Christensen, Karl Bang Larsen, Hanne Bækgaard |
| description | The aim of this investigation was to examine, within a population‐based study of a national cohort comprising Danish survivors of allo‐SCT (n = 148), the long‐term effects of allo‐SCT in children and young adults. Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the HADS. Allo‐SCT‐related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used. Factors negatively influencing the SF‐36 subscales included female gender; TBI; stem cells derived from PB; older age at time of questioning; and living alone. Factors significantly (p < 0.05) influencing HADS were transplantation with stem cells derived from PB and being underweight at time of questioning (median values were within normal range). Overall scores of allo‐SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life ( |
| doi_str_mv | 10.1111/petr.12713 |
| format | article |
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Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the HADS. Allo‐SCT‐related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used. Factors negatively influencing the SF‐36 subscales included female gender; TBI; stem cells derived from PB; older age at time of questioning; and living alone. Factors significantly (p < 0.05) influencing HADS were transplantation with stem cells derived from PB and being underweight at time of questioning (median values were within normal range). Overall scores of allo‐SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life (<25) and whose survival period extended beyond 10 yr (mean) from SCT, showed similar levels of anxiety, depression, and physical and emotional well‐being to those of the normal population.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.12713</identifier><identifier>PMID: 27231147</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; adolescents ; Adult ; Anxiety - diagnosis ; Anxiety - epidemiology ; Anxiety - etiology ; Child ; Child, Preschool ; Denmark - epidemiology ; depression ; Depression - diagnosis ; Depression - epidemiology ; Depression - etiology ; Female ; Follow-Up Studies ; graft-vs.-host disease ; Health Status ; Health Status Indicators ; hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - psychology ; Humans ; Infant ; Infant, Newborn ; Male ; Mental Health ; pediatric ; Quality of Life - psychology ; quality-of-life ; Survivors - psychology ; Transplantation, Homologous ; Young Adult</subject><ispartof>Pediatric transplantation, 2016-08, Vol.20 (5), p.697-706</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4703-deaab1a0f1fc41c6a1f241f58291e949ccfb3323d889f46dac054894bca33b5c3</citedby><cites>FETCH-LOGICAL-c4703-deaab1a0f1fc41c6a1f241f58291e949ccfb3323d889f46dac054894bca33b5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27231147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Josef Nathan</creatorcontrib><creatorcontrib>Gøtzsche, Frederik</creatorcontrib><creatorcontrib>Heilmann, Carsten</creatorcontrib><creatorcontrib>Sengeløv, Henrik</creatorcontrib><creatorcontrib>Adamsen, Lis</creatorcontrib><creatorcontrib>Christensen, Karl Bang</creatorcontrib><creatorcontrib>Larsen, Hanne Bækgaard</creatorcontrib><title>Physical and emotional well-being of survivors of childhood and young adult allo-SCT - A Danish national cohort study</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplantation</addtitle><description>The aim of this investigation was to examine, within a population‐based study of a national cohort comprising Danish survivors of allo‐SCT (n = 148), the long‐term effects of allo‐SCT in children and young adults. Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the HADS. Allo‐SCT‐related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used. Factors negatively influencing the SF‐36 subscales included female gender; TBI; stem cells derived from PB; older age at time of questioning; and living alone. Factors significantly (p < 0.05) influencing HADS were transplantation with stem cells derived from PB and being underweight at time of questioning (median values were within normal range). Overall scores of allo‐SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life (<25) and whose survival period extended beyond 10 yr (mean) from SCT, showed similar levels of anxiety, depression, and physical and emotional well‐being to those of the normal population.</description><subject>Adolescent</subject><subject>adolescents</subject><subject>Adult</subject><subject>Anxiety - diagnosis</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Denmark - epidemiology</subject><subject>depression</subject><subject>Depression - diagnosis</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>graft-vs.-host disease</subject><subject>Health Status</subject><subject>Health Status Indicators</subject><subject>hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Mental Health</subject><subject>pediatric</subject><subject>Quality of Life - psychology</subject><subject>quality-of-life</subject><subject>Survivors - psychology</subject><subject>Transplantation, Homologous</subject><subject>Young Adult</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAURi0Eog_Y8AOQlwjJxTd2nGRZDaUgjWAEw2NnOX4Qgyce7KRt_j2ZR7tE3I3vlc53JOtD6AXQC5jnzdYO6QKKCtgjdAqsaQijXDze7xVhwIsTdJbzL0pB8Jo_RSdFVTAAXp2icdVN2WsVsOoNtps4-NjP160NgbTW9z9xdDiP6cbfxJR3h-58MF2MZh-Z4jgzyoxhwCqESL4s1pjgS_xW9T53uFdHo45dTAPOw2imZ-iJUyHb58f3HH19d7VevCfLT9cfFpdLonlFGTFWqRYUdeA0By0UuIKDK-uiAdvwRmvXMlYwU9eN48IoTUteN7zVirG21OwcvTp4tyn-GW0e5MZnPX9N9TaOWUJNa1FzAeJ_UKhFSYHO6OsDqlPMOVknt8lvVJokULlrRO4akftGZvjl0Tu2G2se0PsKZgAOwK0PdvqHSq6u1p_vpeSQ8Xmwdw8ZlX5LUbGqlN8_XssC2OpbUf6QS_YXrJ6lzA</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Jensen, Josef Nathan</creator><creator>Gøtzsche, Frederik</creator><creator>Heilmann, Carsten</creator><creator>Sengeløv, Henrik</creator><creator>Adamsen, Lis</creator><creator>Christensen, Karl Bang</creator><creator>Larsen, Hanne Bækgaard</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201608</creationdate><title>Physical and emotional well-being of survivors of childhood and young adult allo-SCT - A Danish national cohort study</title><author>Jensen, Josef Nathan ; Gøtzsche, Frederik ; Heilmann, Carsten ; Sengeløv, Henrik ; Adamsen, Lis ; Christensen, Karl Bang ; Larsen, Hanne Bækgaard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4703-deaab1a0f1fc41c6a1f241f58291e949ccfb3323d889f46dac054894bca33b5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>adolescents</topic><topic>Adult</topic><topic>Anxiety - diagnosis</topic><topic>Anxiety - epidemiology</topic><topic>Anxiety - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Denmark - epidemiology</topic><topic>depression</topic><topic>Depression - diagnosis</topic><topic>Depression - epidemiology</topic><topic>Depression - etiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>graft-vs.-host disease</topic><topic>Health Status</topic><topic>Health Status Indicators</topic><topic>hematopoietic stem cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Mental Health</topic><topic>pediatric</topic><topic>Quality of Life - psychology</topic><topic>quality-of-life</topic><topic>Survivors - psychology</topic><topic>Transplantation, Homologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Josef Nathan</creatorcontrib><creatorcontrib>Gøtzsche, Frederik</creatorcontrib><creatorcontrib>Heilmann, Carsten</creatorcontrib><creatorcontrib>Sengeløv, Henrik</creatorcontrib><creatorcontrib>Adamsen, Lis</creatorcontrib><creatorcontrib>Christensen, Karl Bang</creatorcontrib><creatorcontrib>Larsen, Hanne Bækgaard</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Josef Nathan</au><au>Gøtzsche, Frederik</au><au>Heilmann, Carsten</au><au>Sengeløv, Henrik</au><au>Adamsen, Lis</au><au>Christensen, Karl Bang</au><au>Larsen, Hanne Bækgaard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical and emotional well-being of survivors of childhood and young adult allo-SCT - A Danish national cohort study</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplantation</addtitle><date>2016-08</date><risdate>2016</risdate><volume>20</volume><issue>5</issue><spage>697</spage><epage>706</epage><pages>697-706</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>The aim of this investigation was to examine, within a population‐based study of a national cohort comprising Danish survivors of allo‐SCT (n = 148), the long‐term effects of allo‐SCT in children and young adults. Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the HADS. Allo‐SCT‐related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used. Factors negatively influencing the SF‐36 subscales included female gender; TBI; stem cells derived from PB; older age at time of questioning; and living alone. Factors significantly (p < 0.05) influencing HADS were transplantation with stem cells derived from PB and being underweight at time of questioning (median values were within normal range). Overall scores of allo‐SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life (<25) and whose survival period extended beyond 10 yr (mean) from SCT, showed similar levels of anxiety, depression, and physical and emotional well‐being to those of the normal population.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>27231147</pmid><doi>10.1111/petr.12713</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1397-3142 |
| ispartof | Pediatric transplantation, 2016-08, Vol.20 (5), p.697-706 |
| issn | 1397-3142 1399-3046 |
| language | eng |
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| source | Wiley |
| subjects | Adolescent adolescents Adult Anxiety - diagnosis Anxiety - epidemiology Anxiety - etiology Child Child, Preschool Denmark - epidemiology depression Depression - diagnosis Depression - epidemiology Depression - etiology Female Follow-Up Studies graft-vs.-host disease Health Status Health Status Indicators hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - psychology Humans Infant Infant, Newborn Male Mental Health pediatric Quality of Life - psychology quality-of-life Survivors - psychology Transplantation, Homologous Young Adult |
| title | Physical and emotional well-being of survivors of childhood and young adult allo-SCT - A Danish national cohort study |
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