Genetic characteristics of inflammatory bowel disease in a Japanese population

Background Crohn’s disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susce...

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Bibliographic Details
Published in:Journal of gastroenterology 2016-07, Vol.51 (7), p.672-681
Main Authors: Fuyuno, Yuta, Yamazaki, Keiko, Takahashi, Atsushi, Esaki, Motohiro, Kawaguchi, Takaaki, Takazoe, Masakazu, Matsumoto, Takayuki, Matsui, Toshiyuki, Tanaka, Hiroki, Motoya, Satoshi, Suzuki, Yasuo, Kiyohara, Yutaka, Kitazono, Takanari, Kubo, Michiaki
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Analysis
Asian Continental Ancestry Group - genetics
Case-Control Studies
Colitis, Ulcerative - ethnology
Colitis, Ulcerative - genetics
Colorectal Surgery
Crohn Disease - ethnology
Crohn Disease - genetics
Disease susceptibility
European Continental Ancestry Group - genetics
Female
Gastroenterology
Genetic Predisposition to Disease - genetics
Genetic research
Genome-Wide Association Study
Genomics
Hepatology
Humans
Inflammatory bowel disease
Japan
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article—Alimentary Tract
Polymorphism, Single Nucleotide - genetics
Single nucleotide polymorphisms
Surgical Oncology
Ulcerative colitis
Young Adult
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Summary:Background Crohn’s disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japanese population. Methods We performed a GWAS using imputed genotypes of 743 IBD patients (372 with CD and 371 with UC) and 3321 controls. Using 100 tag single-nucleotide polymorphisms (SNPs) ( P  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-015-1135-3