The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats

Highlights • DLF lesion increases the effect of muscimol in the initiation of neuropathic pain. • DLF lesion increases the effect of baclofen in the initiation of neuropathic pain. • DLF lesion reduces the effect of baclofen in the maintenance of neuropathic pain. • DLF lesion blocks the proallodyni...

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Bibliographic Details
Published in:Brain research bulletin 2016-06, Vol.124, p.103-115
Main Authors: Dias, Quintino Moura, Prado, Wiliam A
Format: Article
Language:English
Subjects:
Allodynia
Animals
Baclofen - administration & dosage
Baclofen - analogs & derivatives
Bicuculline - administration & dosage
Descending facilitatory mechanisms
Dorsolateral funiculus lesion
Functional Laterality
GABA Agents - administration & dosage
Hyperalgesia - drug therapy
Hyperalgesia - etiology
Injections, Spinal
Ligation - adverse effects
Male
Muscimol - administration & dosage
Neuralgia - complications
Neuralgia - drug therapy
Neuralgia - etiology
Neurology
Neuropathic pain
Pain Measurement
Pain Threshold - drug effects
Physical Stimulation
Rats
Rats, Wistar
Spinal Cord Dorsal Horn - drug effects
Spinal Cord Dorsal Horn - pathology
Spinal GABAergic modulation
Spinal Nerves - injuries
Statistics, Nonparametric
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Summary:Highlights • DLF lesion increases the effect of muscimol in the initiation of neuropathic pain. • DLF lesion increases the effect of baclofen in the initiation of neuropathic pain. • DLF lesion reduces the effect of baclofen in the maintenance of neuropathic pain. • DLF lesion blocks the proallodynic effect of phaclofen in neuropathic pain
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.04.001