Polysaccharide peptides from Coriolus versicolor exert differential immunomodulatory effects on blood lymphocytes and breast cancer cell line MCF-7 in vitro

Highlights • Polysaccharopeptides induce TNF-α-dependent decrease in MCF-7 cells viability. • The PBP acts as blood lymphocytes mitogen and cytokine release activator. • The PBP acts on target cells in inverted dose response manner.

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Bibliographic Details
Published in:Immunology letters 2016-06, Vol.174, p.37-44
Main Authors: Kowalczewska, Małgorzata, Piotrowski, Jakub, Jędrzejewski, Tomasz, Kozak, Wiesław
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antineoplastic Agents - pharmacology
Ascomycota - chemistry
Breast Neoplasms - immunology
Breast Neoplasms - metabolism
Cell Proliferation - drug effects
Coriolus versicolor
Cytokine
Cytokines - genetics
Cytokines - metabolism
Female
Gene Expression
Humans
Immunologic Factors - pharmacology
Lymphocyte Activation - drug effects
Lymphocyte Activation - immunology
Lymphocytes
Lymphocytes - drug effects
Lymphocytes - immunology
Lymphocytes - metabolism
MCF-7 cells
MCF-7 Cells - drug effects
MTT test
Protein-bound polysaccharides
Proteoglycans - pharmacology
qRT-PCR
Rats
RNA, Messenger - genetics
RNA, Messenger - metabolism
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor Necrosis Factor-alpha - metabolism
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Description
Summary:Highlights • Polysaccharopeptides induce TNF-α-dependent decrease in MCF-7 cells viability. • The PBP acts as blood lymphocytes mitogen and cytokine release activator. • The PBP acts on target cells in inverted dose response manner.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.04.010