Susac’s syndrome: Leptomeningeal enhancement on 3D FLAIR MRI

Background: Contrast-enhanced (ce) fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI) has recently been shown to identify leptomeningeal pathology in multiple sclerosis. Objective: To demonstrate leptomeningeal enhancement on three-dimensional (3D) FLAIR in a case of Susac’s...

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Bibliographic Details
Published in:Multiple sclerosis 2016-06, Vol.22 (7), p.972-974
Main Authors: Engisch, Renate, Titelbaum, David S, Chilver-Stainer, Lara, Kellner-Weldon, Frauke
Format: Article
Language:English
Subjects:
Adult
Angiography
Contrast Media - administration & dosage
Fluorescein
Fluorescein Angiography
Humans
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Meninges
Meninges - diagnostic imaging
Meninges - drug effects
Multiple sclerosis
NMR
Nuclear magnetic resonance
Predictive Value of Tests
Retina
Severity of Illness Index
Steroids - administration & dosage
Susac Syndrome - diagnostic imaging
Susac Syndrome - drug therapy
Time Factors
Treatment Outcome
Vascular diseases
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Summary:Background: Contrast-enhanced (ce) fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI) has recently been shown to identify leptomeningeal pathology in multiple sclerosis. Objective: To demonstrate leptomeningeal enhancement on three-dimensional (3D) FLAIR in a case of Susac’s syndrome. Methods: Leptomeningeal enhancement was correlated with clinical activity over 20 months and compared to retinal fluorescein angiography. Results: The size, number, and location of leptomeningeal enhancement varied over time and generally correlated with symptom severity. The appearance was remarkably similar to that of retinal vasculopathy. Conclusion: Ce 3D FLAIR may aid in diagnosis and understanding of pathophysiology in Susac’s syndrome and may serve as a biomarker for disease activity.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458516636836