Attenuation of Oxidative and Nitrosative Stress in Cortical Area Associates with Antidepressant-like Effects of Tropisetron in Male Mice following Social Isolation Stress

• Published in: Brain research bulletin 2016-06, Vol.124, p.150-163
• Main Authors: Haj-Mirzaian, Arya, Amiri, Shayan, Amini-Khoei, Hossein, Rahimi-Balaei, Maryam, Kordjazy, Nastaran, Olson, Carl O, Rastegar, Mojgan, Naserzadeh, Parvaneh, Marzban, Hassan, Dehpour, Ahmad Reza, Hosseini, Mir-Jamal, Mehr, Shahram Ejtemaei
• Format: Article
• Language: English
• Subjects: Adolescence social isolation stress; Animals; Animals, Newborn; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Depressive-like behaviors; Enzyme Inhibitors - pharmacology; Exploratory Behavior - drug effects; Indoles - pharmacology; Indoles - therapeutic use; Male; Mice; Mitochondrial dysfunction; Motivation - drug effects; Neurology; NG-Nitroarginine Methyl Ester - pharmacology; Nitrates - metabolism; Nitric oxide; Nitrosation - drug effects; Oxidative Stress - drug effects; Reactive Oxygen Species - metabolism; Social Isolation - psychology; Stress, Psychological - drug therapy; Stress, Psychological - pathology; Tropisetron
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2016.04.018

Highlights • Adolescence SIS provoked depressive–like behaviors in socially isolated male mice. • SIS induced mitochondrial dysfunction and O&NS stress in the cortical areas. • Tropisetron attenuated the negative effect of SIS on behavioral tests. • Tropisetron reversed mitochondrial dysfunction and O&NS stress of cortex. • Nitrergic system is partially involved in protective effects of tropisetron.