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Attenuation of Oxidative and Nitrosative Stress in Cortical Area Associates with Antidepressant-like Effects of Tropisetron in Male Mice following Social Isolation Stress
Highlights • Adolescence SIS provoked depressive–like behaviors in socially isolated male mice. • SIS induced mitochondrial dysfunction and O&NS stress in the cortical areas. • Tropisetron attenuated the negative effect of SIS on behavioral tests. • Tropisetron reversed mitochondrial dysfunction...
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| Published in: | Brain research bulletin 2016-06, Vol.124, p.150-163 |
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| Main Authors: | , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c468t-48b5c512d3c9ee4eb98d3a50acf66094c5e9709dd7f4d6bf9421a03af35635f13 |
| container_end_page | 163 |
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| container_title | Brain research bulletin |
| container_volume | 124 |
| creator | Haj-Mirzaian, Arya Amiri, Shayan Amini-Khoei, Hossein Rahimi-Balaei, Maryam Kordjazy, Nastaran Olson, Carl O Rastegar, Mojgan Naserzadeh, Parvaneh Marzban, Hassan Dehpour, Ahmad Reza Hosseini, Mir-Jamal Mehr, Shahram Ejtemaei |
| description | Highlights • Adolescence SIS provoked depressive–like behaviors in socially isolated male mice. • SIS induced mitochondrial dysfunction and O&NS stress in the cortical areas. • Tropisetron attenuated the negative effect of SIS on behavioral tests. • Tropisetron reversed mitochondrial dysfunction and O&NS stress of cortex. • Nitrergic system is partially involved in protective effects of tropisetron. |
| doi_str_mv | 10.1016/j.brainresbull.2016.04.018 |
| format | article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-48b5c512d3c9ee4eb98d3a50acf66094c5e9709dd7f4d6bf9421a03af35635f13</citedby><cites>FETCH-LOGICAL-c468t-48b5c512d3c9ee4eb98d3a50acf66094c5e9709dd7f4d6bf9421a03af35635f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27129671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haj-Mirzaian, Arya</creatorcontrib><creatorcontrib>Amiri, Shayan</creatorcontrib><creatorcontrib>Amini-Khoei, Hossein</creatorcontrib><creatorcontrib>Rahimi-Balaei, Maryam</creatorcontrib><creatorcontrib>Kordjazy, Nastaran</creatorcontrib><creatorcontrib>Olson, Carl O</creatorcontrib><creatorcontrib>Rastegar, Mojgan</creatorcontrib><creatorcontrib>Naserzadeh, Parvaneh</creatorcontrib><creatorcontrib>Marzban, Hassan</creatorcontrib><creatorcontrib>Dehpour, Ahmad Reza</creatorcontrib><creatorcontrib>Hosseini, Mir-Jamal</creatorcontrib><creatorcontrib>Mehr, Shahram Ejtemaei</creatorcontrib><title>Attenuation of Oxidative and Nitrosative Stress in Cortical Area Associates with Antidepressant-like Effects of Tropisetron in Male Mice following Social Isolation Stress</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Highlights • Adolescence SIS provoked depressive–like behaviors in socially isolated male mice. • SIS induced mitochondrial dysfunction and O&NS stress in the cortical areas. • Tropisetron attenuated the negative effect of SIS on behavioral tests. • Tropisetron reversed mitochondrial dysfunction and O&NS stress of cortex. • Nitrergic system is partially involved in protective effects of tropisetron.</description><subject>Adolescence social isolation stress</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Depressive-like behaviors</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Exploratory Behavior - drug effects</subject><subject>Indoles - pharmacology</subject><subject>Indoles - therapeutic use</subject><subject>Male</subject><subject>Mice</subject><subject>Mitochondrial dysfunction</subject><subject>Motivation - drug effects</subject><subject>Neurology</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitrates - metabolism</subject><subject>Nitric oxide</subject><subject>Nitrosation - drug effects</subject><subject>Oxidative Stress - drug effects</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Social Isolation - psychology</subject><subject>Stress, Psychological - drug therapy</subject><subject>Stress, Psychological - pathology</subject><subject>Tropisetron</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUsFu1DAQjRCILgu_gCxOXBLsOLETDkirbYFKLT1sOVuOPQFvvfZiOy39Jb4SRykIceppNKM3743em6J4Q3BFMGHv9tUQpHEB4jBZW9V5VuGmwqR7UqxIx2lZ84Y_LVaYMlL2NcUnxYsY9xhj1rXseXFSc1L3jJNV8WuTErhJJuMd8iO6-ml0bm4BSafRF5OCj0u_S1kwIuPQ1odklLRoE0CiTYxeGZkgojuTvqONS0bDcQZLl0prbgCdjSOoFGeB6-CPJkLmdTPXpbSALo0CNHpr_Z1x39Bu5rPoPHq73LVIvyyejdJGePVQ18XXj2fX28_lxdWn8-3molQN61LZdEOrWlJrqnqABoa-01S2WKqRMdw3qoWe415rPjaaDWPf1ERiKkfaMtqOhK6LtwvvMfgfE8QkDiYqsFY68FMUpMMd6_qG14-BUt5znsu6eL9AVXY0BhjFMZiDDPeCYDHHKvbi31jFHKvAjcix5uXXDzrTcAD9d_VPjhlwugAgG3NrIIioDDgF2oTsvNDePE7nw380yho3Z30D9xD3fgouWy-IiLXAYjc_2PxfhFGM-7qmvwFRgNNN</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Haj-Mirzaian, Arya</creator><creator>Amiri, Shayan</creator><creator>Amini-Khoei, Hossein</creator><creator>Rahimi-Balaei, Maryam</creator><creator>Kordjazy, Nastaran</creator><creator>Olson, Carl O</creator><creator>Rastegar, Mojgan</creator><creator>Naserzadeh, Parvaneh</creator><creator>Marzban, Hassan</creator><creator>Dehpour, Ahmad Reza</creator><creator>Hosseini, Mir-Jamal</creator><creator>Mehr, Shahram Ejtemaei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160601</creationdate><title>Attenuation of Oxidative and Nitrosative Stress in Cortical Area Associates with Antidepressant-like Effects of Tropisetron in Male Mice following Social Isolation Stress</title><author>Haj-Mirzaian, Arya ; Amiri, Shayan ; Amini-Khoei, Hossein ; Rahimi-Balaei, Maryam ; Kordjazy, Nastaran ; Olson, Carl O ; Rastegar, Mojgan ; Naserzadeh, Parvaneh ; Marzban, Hassan ; Dehpour, Ahmad Reza ; Hosseini, Mir-Jamal ; Mehr, Shahram Ejtemaei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-48b5c512d3c9ee4eb98d3a50acf66094c5e9709dd7f4d6bf9421a03af35635f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescence social isolation stress</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Depressive-like behaviors</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Exploratory Behavior - drug effects</topic><topic>Indoles - pharmacology</topic><topic>Indoles - therapeutic use</topic><topic>Male</topic><topic>Mice</topic><topic>Mitochondrial dysfunction</topic><topic>Motivation - drug effects</topic><topic>Neurology</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitrates - metabolism</topic><topic>Nitric oxide</topic><topic>Nitrosation - drug effects</topic><topic>Oxidative Stress - drug effects</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Social Isolation - psychology</topic><topic>Stress, Psychological - drug therapy</topic><topic>Stress, Psychological - pathology</topic><topic>Tropisetron</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haj-Mirzaian, Arya</creatorcontrib><creatorcontrib>Amiri, Shayan</creatorcontrib><creatorcontrib>Amini-Khoei, Hossein</creatorcontrib><creatorcontrib>Rahimi-Balaei, Maryam</creatorcontrib><creatorcontrib>Kordjazy, Nastaran</creatorcontrib><creatorcontrib>Olson, Carl O</creatorcontrib><creatorcontrib>Rastegar, Mojgan</creatorcontrib><creatorcontrib>Naserzadeh, Parvaneh</creatorcontrib><creatorcontrib>Marzban, Hassan</creatorcontrib><creatorcontrib>Dehpour, Ahmad Reza</creatorcontrib><creatorcontrib>Hosseini, Mir-Jamal</creatorcontrib><creatorcontrib>Mehr, Shahram Ejtemaei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haj-Mirzaian, Arya</au><au>Amiri, Shayan</au><au>Amini-Khoei, Hossein</au><au>Rahimi-Balaei, Maryam</au><au>Kordjazy, Nastaran</au><au>Olson, Carl O</au><au>Rastegar, Mojgan</au><au>Naserzadeh, Parvaneh</au><au>Marzban, Hassan</au><au>Dehpour, Ahmad Reza</au><au>Hosseini, Mir-Jamal</au><au>Mehr, Shahram Ejtemaei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of Oxidative and Nitrosative Stress in Cortical Area Associates with Antidepressant-like Effects of Tropisetron in Male Mice following Social Isolation Stress</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>124</volume><spage>150</spage><epage>163</epage><pages>150-163</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Highlights • Adolescence SIS provoked depressive–like behaviors in socially isolated male mice. • SIS induced mitochondrial dysfunction and O&NS stress in the cortical areas. • Tropisetron attenuated the negative effect of SIS on behavioral tests. • Tropisetron reversed mitochondrial dysfunction and O&NS stress of cortex. • Nitrergic system is partially involved in protective effects of tropisetron.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27129671</pmid><doi>10.1016/j.brainresbull.2016.04.018</doi><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 2016-06, Vol.124, p.150-163 |
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| language | eng |
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| source | Elsevier |
| subjects | Adolescence social isolation stress Animals Animals, Newborn Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Cerebral Cortex - drug effects Cerebral Cortex - metabolism Depressive-like behaviors Enzyme Inhibitors - pharmacology Exploratory Behavior - drug effects Indoles - pharmacology Indoles - therapeutic use Male Mice Mitochondrial dysfunction Motivation - drug effects Neurology NG-Nitroarginine Methyl Ester - pharmacology Nitrates - metabolism Nitric oxide Nitrosation - drug effects Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Social Isolation - psychology Stress, Psychological - drug therapy Stress, Psychological - pathology Tropisetron |
| title | Attenuation of Oxidative and Nitrosative Stress in Cortical Area Associates with Antidepressant-like Effects of Tropisetron in Male Mice following Social Isolation Stress |
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