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Association of adherence to a Mediterranean diet with glycemic control and cardiovascular risk factors in youth with type I diabetes: the SEARCH Nutrition Ancillary Study
Background/Objectives: This study aimed to determine the association between a Mediterranean diet and glycemic control and other cardiovascular risk factors among youth with type I diabetes (TID). Subjects/Methods: Incident TID cases aged
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| Published in: | European journal of clinical nutrition 2016-07, Vol.70 (7), p.802-807 |
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| cites | cdi_FETCH-LOGICAL-c588t-3a5845847c675b62fc1dbaa69df73668bbdfbba094586b03a234895c899845fa3 |
| container_end_page | 807 |
| container_issue | 7 |
| container_start_page | 802 |
| container_title | European journal of clinical nutrition |
| container_volume | 70 |
| creator | Zhong, V W Lamichhane, A P Crandell, J L Couch, S C Liese, A D The, N S Tzeel, B A Dabelea, D Lawrence, J M Marcovina, S M Kim, G Mayer-Davis, E J |
| description | Background/Objectives:
This study aimed to determine the association between a Mediterranean diet and glycemic control and other cardiovascular risk factors among youth with type I diabetes (TID).
Subjects/Methods:
Incident TID cases aged |
| doi_str_mv | 10.1038/ejcn.2016.8 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808689954</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A457303518</galeid><sourcerecordid>A457303518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c588t-3a5845847c675b62fc1dbaa69df73668bbdfbba094586b03a234895c899845fa3</originalsourceid><addsrcrecordid>eNqNklGL1DAQx4so3nr65LsEBBG0a9omaerbspzewang6XOYptPdrN1kTVJlv5Kf0vTu1DtZRBIIZH7_fyYzk2WPCzovaCVf4UbbeUkLMZd3slnBapFzwejdbEYbzvKK0vooexDChtIUrMv72VEpGipZWcyyH4sQnDYQjbPE9QS6NXq0Gkl0BMg77ExE78EiWNIZjOS7iWuyGvYat0YT7Wz0biBgO6LBd8Z9g6DHATzxJnwhPejofCDGkr0bk_JSHvc7JGfJD1qMGF6TuEZycbL4uDwl78fozWU6C6vNkJz25CKO3f5hdq-HIeCj6_M4-_zm5NPyND__8PZsuTjPNZcy5hVwydKutah5K8peF10LIJquryshZNt2fdsCbRIkWlpBWTHZcC2bJul6qI6z51e-O---jhii2pqgMWVi0Y1BFZJKkWjO_gctmWh4IxL69C9040Zv00dUKVgpq2T5T2ryopTVvPlDrWBAZWzvogc9Pa0WjNcVrXghE5UfoFZo0cPgLPYmXd_i5wf4tLqp0wcFz24I1ghDXAc3jFPzwm3wxRWovQvBY6923mxTY1VB1TTDapphNc2wmugn1zUY2y12v9lfQ5uAl1dASCG7Qn-jSAf8fgIwivle</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1802004759</pqid></control><display><type>article</type><title>Association of adherence to a Mediterranean diet with glycemic control and cardiovascular risk factors in youth with type I diabetes: the SEARCH Nutrition Ancillary Study</title><source>Springer Link</source><source>EZB Electronic Journals Library</source><creator>Zhong, V W ; Lamichhane, A P ; Crandell, J L ; Couch, S C ; Liese, A D ; The, N S ; Tzeel, B A ; Dabelea, D ; Lawrence, J M ; Marcovina, S M ; Kim, G ; Mayer-Davis, E J</creator><creatorcontrib>Zhong, V W ; Lamichhane, A P ; Crandell, J L ; Couch, S C ; Liese, A D ; The, N S ; Tzeel, B A ; Dabelea, D ; Lawrence, J M ; Marcovina, S M ; Kim, G ; Mayer-Davis, E J</creatorcontrib><description>Background/Objectives:
This study aimed to determine the association between a Mediterranean diet and glycemic control and other cardiovascular risk factors among youth with type I diabetes (TID).
Subjects/Methods:
Incident TID cases aged <20 years at diagnosis between 2002 and 2005 were included. Participants were seen at baseline (
N
=793), 1-year (
N
=512) and 5-year follow-up visits (
N
=501). Mediterranean diet score was assessed using a modified KIDMED index (mKIDMED). Multivariate linear regression and longitudinal mixed model were applied to determine the association between mKIDMED score and log-HbA1c, lipids, blood pressure (BP) and obesity.
Results:
In cross-sectional analyses using baseline data, for individuals with the hemoglobin A1c (HbA1c) of 7.5%, a two-point higher mKIDMED score (1 s.d.) was associated with 0.15% lower HbA1c (
P
=0.02). A two-point higher mKIDMED score was associated with 4.0 mg/dl lower total cholesterol (TC) (
P
=0.006), 3.4 mg/dl lower low-density lipoprotein cholesterol (LDL-C) (
P
=0.004), 3.9 mg/dl lower non-high-density lipoprotein cholesterol (non-HDL-C) (
P
=0.004) and 0.07 lower LDL-C/HDL-C ratio (
P
=0.02). Using longitudinal data, a two-point increase in mKIDMED score was associated with 0.01% lower log-HbA1c (
P
=0.07), 1.8 mg/dl lower TC (
P
=0.05), 1.6 mg/dl lower LDL-C (
P
=0.03) and 1.8 mg/dl lower non-HDL-C (
P
=0.03) than would otherwise have been expected. HbA1c mediated ∼20% of the association for lipids in both cross-sectional and longitudinal models. An unexpected positive association between mKIDMED score and systolic BP was found among non-Hispanic white youth in cross-sectional analyses (
P
=0.009). Mediterranean diet was not associated with obesity.
Conclusions:
Mediterranean diet may improve glycemic control and cardiovascular health in TID youth.</description><identifier>ISSN: 0954-3007</identifier><identifier>ISSN: 1476-5640</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2016.8</identifier><identifier>PMID: 26908421</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163 ; 692/499 ; 692/699/2743 ; 692/699/75 ; Adolescent ; Adult ; Blood Glucose - metabolism ; Blood Pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular system ; Child ; Child, Preschool ; Cholesterol ; Clinical Nutrition ; Cross-Sectional Studies ; Density ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diet therapy ; Diabetes Mellitus, Type 1 - drug therapy ; Diet ; Diet, Mediterranean ; Epidemiology ; Feeding Behavior ; Female ; Follow-Up Studies ; Glucose metabolism ; Glycated Hemoglobin - metabolism ; Glycemic index ; Health aspects ; Health risk assessment ; Health risks ; Hemoglobin ; High density lipoprotein ; Humans ; Insulin - therapeutic use ; Internal Medicine ; Lipids ; Lipids - blood ; Lipoproteins - blood ; Low density lipoprotein ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Nutrition ; Nutrition research ; Obesity ; Observations ; original-article ; Patient Compliance ; Physiological aspects ; Public Health ; Regression models ; Risk analysis ; Risk Factors ; Risk management ; Teenagers ; Type 1 diabetes ; White People ; Young Adult ; Youth</subject><ispartof>European journal of clinical nutrition, 2016-07, Vol.70 (7), p.802-807</ispartof><rights>Macmillan Publishers Limited 2016</rights><rights>COPYRIGHT 2016 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2016</rights><rights>Macmillan Publishers Limited 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-3a5845847c675b62fc1dbaa69df73668bbdfbba094586b03a234895c899845fa3</citedby><cites>FETCH-LOGICAL-c588t-3a5845847c675b62fc1dbaa69df73668bbdfbba094586b03a234895c899845fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26908421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhong, V W</creatorcontrib><creatorcontrib>Lamichhane, A P</creatorcontrib><creatorcontrib>Crandell, J L</creatorcontrib><creatorcontrib>Couch, S C</creatorcontrib><creatorcontrib>Liese, A D</creatorcontrib><creatorcontrib>The, N S</creatorcontrib><creatorcontrib>Tzeel, B A</creatorcontrib><creatorcontrib>Dabelea, D</creatorcontrib><creatorcontrib>Lawrence, J M</creatorcontrib><creatorcontrib>Marcovina, S M</creatorcontrib><creatorcontrib>Kim, G</creatorcontrib><creatorcontrib>Mayer-Davis, E J</creatorcontrib><title>Association of adherence to a Mediterranean diet with glycemic control and cardiovascular risk factors in youth with type I diabetes: the SEARCH Nutrition Ancillary Study</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives:
This study aimed to determine the association between a Mediterranean diet and glycemic control and other cardiovascular risk factors among youth with type I diabetes (TID).
Subjects/Methods:
Incident TID cases aged <20 years at diagnosis between 2002 and 2005 were included. Participants were seen at baseline (
N
=793), 1-year (
N
=512) and 5-year follow-up visits (
N
=501). Mediterranean diet score was assessed using a modified KIDMED index (mKIDMED). Multivariate linear regression and longitudinal mixed model were applied to determine the association between mKIDMED score and log-HbA1c, lipids, blood pressure (BP) and obesity.
Results:
In cross-sectional analyses using baseline data, for individuals with the hemoglobin A1c (HbA1c) of 7.5%, a two-point higher mKIDMED score (1 s.d.) was associated with 0.15% lower HbA1c (
P
=0.02). A two-point higher mKIDMED score was associated with 4.0 mg/dl lower total cholesterol (TC) (
P
=0.006), 3.4 mg/dl lower low-density lipoprotein cholesterol (LDL-C) (
P
=0.004), 3.9 mg/dl lower non-high-density lipoprotein cholesterol (non-HDL-C) (
P
=0.004) and 0.07 lower LDL-C/HDL-C ratio (
P
=0.02). Using longitudinal data, a two-point increase in mKIDMED score was associated with 0.01% lower log-HbA1c (
P
=0.07), 1.8 mg/dl lower TC (
P
=0.05), 1.6 mg/dl lower LDL-C (
P
=0.03) and 1.8 mg/dl lower non-HDL-C (
P
=0.03) than would otherwise have been expected. HbA1c mediated ∼20% of the association for lipids in both cross-sectional and longitudinal models. An unexpected positive association between mKIDMED score and systolic BP was found among non-Hispanic white youth in cross-sectional analyses (
P
=0.009). Mediterranean diet was not associated with obesity.
Conclusions:
Mediterranean diet may improve glycemic control and cardiovascular health in TID youth.</description><subject>692/163</subject><subject>692/499</subject><subject>692/699/2743</subject><subject>692/699/75</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cholesterol</subject><subject>Clinical Nutrition</subject><subject>Cross-Sectional Studies</subject><subject>Density</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - diet therapy</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diet</subject><subject>Diet, Mediterranean</subject><subject>Epidemiology</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucose metabolism</subject><subject>Glycated Hemoglobin - metabolism</subject><subject>Glycemic index</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hemoglobin</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Insulin - therapeutic use</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nutrition</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Observations</subject><subject>original-article</subject><subject>Patient Compliance</subject><subject>Physiological aspects</subject><subject>Public Health</subject><subject>Regression models</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Risk management</subject><subject>Teenagers</subject><subject>Type 1 diabetes</subject><subject>White People</subject><subject>Young Adult</subject><subject>Youth</subject><issn>0954-3007</issn><issn>1476-5640</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNklGL1DAQx4so3nr65LsEBBG0a9omaerbspzewang6XOYptPdrN1kTVJlv5Kf0vTu1DtZRBIIZH7_fyYzk2WPCzovaCVf4UbbeUkLMZd3slnBapFzwejdbEYbzvKK0vooexDChtIUrMv72VEpGipZWcyyH4sQnDYQjbPE9QS6NXq0Gkl0BMg77ExE78EiWNIZjOS7iWuyGvYat0YT7Wz0biBgO6LBd8Z9g6DHATzxJnwhPejofCDGkr0bk_JSHvc7JGfJD1qMGF6TuEZycbL4uDwl78fozWU6C6vNkJz25CKO3f5hdq-HIeCj6_M4-_zm5NPyND__8PZsuTjPNZcy5hVwydKutah5K8peF10LIJquryshZNt2fdsCbRIkWlpBWTHZcC2bJul6qI6z51e-O---jhii2pqgMWVi0Y1BFZJKkWjO_gctmWh4IxL69C9040Zv00dUKVgpq2T5T2ryopTVvPlDrWBAZWzvogc9Pa0WjNcVrXghE5UfoFZo0cPgLPYmXd_i5wf4tLqp0wcFz24I1ghDXAc3jFPzwm3wxRWovQvBY6923mxTY1VB1TTDapphNc2wmugn1zUY2y12v9lfQ5uAl1dASCG7Qn-jSAf8fgIwivle</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Zhong, V W</creator><creator>Lamichhane, A P</creator><creator>Crandell, J L</creator><creator>Couch, S C</creator><creator>Liese, A D</creator><creator>The, N S</creator><creator>Tzeel, B A</creator><creator>Dabelea, D</creator><creator>Lawrence, J M</creator><creator>Marcovina, S M</creator><creator>Kim, G</creator><creator>Mayer-Davis, E J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>Association of adherence to a Mediterranean diet with glycemic control and cardiovascular risk factors in youth with type I diabetes: the SEARCH Nutrition Ancillary Study</title><author>Zhong, V W ; Lamichhane, A P ; Crandell, J L ; Couch, S C ; Liese, A D ; The, N S ; Tzeel, B A ; Dabelea, D ; Lawrence, J M ; Marcovina, S M ; Kim, G ; Mayer-Davis, E J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-3a5845847c675b62fc1dbaa69df73668bbdfbba094586b03a234895c899845fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>692/163</topic><topic>692/499</topic><topic>692/699/2743</topic><topic>692/699/75</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cholesterol</topic><topic>Clinical Nutrition</topic><topic>Cross-Sectional Studies</topic><topic>Density</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - diet therapy</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diet</topic><topic>Diet, Mediterranean</topic><topic>Epidemiology</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucose metabolism</topic><topic>Glycated Hemoglobin - metabolism</topic><topic>Glycemic index</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hemoglobin</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Insulin - therapeutic use</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoproteins - blood</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Nutrition</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Observations</topic><topic>original-article</topic><topic>Patient Compliance</topic><topic>Physiological aspects</topic><topic>Public Health</topic><topic>Regression models</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Risk management</topic><topic>Teenagers</topic><topic>Type 1 diabetes</topic><topic>White People</topic><topic>Young Adult</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, V W</creatorcontrib><creatorcontrib>Lamichhane, A P</creatorcontrib><creatorcontrib>Crandell, J L</creatorcontrib><creatorcontrib>Couch, S C</creatorcontrib><creatorcontrib>Liese, A D</creatorcontrib><creatorcontrib>The, N S</creatorcontrib><creatorcontrib>Tzeel, B A</creatorcontrib><creatorcontrib>Dabelea, D</creatorcontrib><creatorcontrib>Lawrence, J M</creatorcontrib><creatorcontrib>Marcovina, S M</creatorcontrib><creatorcontrib>Kim, G</creatorcontrib><creatorcontrib>Mayer-Davis, E J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, V W</au><au>Lamichhane, A P</au><au>Crandell, J L</au><au>Couch, S C</au><au>Liese, A D</au><au>The, N S</au><au>Tzeel, B A</au><au>Dabelea, D</au><au>Lawrence, J M</au><au>Marcovina, S M</au><au>Kim, G</au><au>Mayer-Davis, E J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of adherence to a Mediterranean diet with glycemic control and cardiovascular risk factors in youth with type I diabetes: the SEARCH Nutrition Ancillary Study</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>70</volume><issue>7</issue><spage>802</spage><epage>807</epage><pages>802-807</pages><issn>0954-3007</issn><issn>1476-5640</issn><eissn>1476-5640</eissn><abstract>Background/Objectives:
This study aimed to determine the association between a Mediterranean diet and glycemic control and other cardiovascular risk factors among youth with type I diabetes (TID).
Subjects/Methods:
Incident TID cases aged <20 years at diagnosis between 2002 and 2005 were included. Participants were seen at baseline (
N
=793), 1-year (
N
=512) and 5-year follow-up visits (
N
=501). Mediterranean diet score was assessed using a modified KIDMED index (mKIDMED). Multivariate linear regression and longitudinal mixed model were applied to determine the association between mKIDMED score and log-HbA1c, lipids, blood pressure (BP) and obesity.
Results:
In cross-sectional analyses using baseline data, for individuals with the hemoglobin A1c (HbA1c) of 7.5%, a two-point higher mKIDMED score (1 s.d.) was associated with 0.15% lower HbA1c (
P
=0.02). A two-point higher mKIDMED score was associated with 4.0 mg/dl lower total cholesterol (TC) (
P
=0.006), 3.4 mg/dl lower low-density lipoprotein cholesterol (LDL-C) (
P
=0.004), 3.9 mg/dl lower non-high-density lipoprotein cholesterol (non-HDL-C) (
P
=0.004) and 0.07 lower LDL-C/HDL-C ratio (
P
=0.02). Using longitudinal data, a two-point increase in mKIDMED score was associated with 0.01% lower log-HbA1c (
P
=0.07), 1.8 mg/dl lower TC (
P
=0.05), 1.6 mg/dl lower LDL-C (
P
=0.03) and 1.8 mg/dl lower non-HDL-C (
P
=0.03) than would otherwise have been expected. HbA1c mediated ∼20% of the association for lipids in both cross-sectional and longitudinal models. An unexpected positive association between mKIDMED score and systolic BP was found among non-Hispanic white youth in cross-sectional analyses (
P
=0.009). Mediterranean diet was not associated with obesity.
Conclusions:
Mediterranean diet may improve glycemic control and cardiovascular health in TID youth.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26908421</pmid><doi>10.1038/ejcn.2016.8</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2016-07, Vol.70 (7), p.802-807 |
| issn | 0954-3007 1476-5640 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808689954 |
| source | Springer Link; EZB Electronic Journals Library |
| subjects | 692/163 692/499 692/699/2743 692/699/75 Adolescent Adult Blood Glucose - metabolism Blood Pressure Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cardiovascular system Child Child, Preschool Cholesterol Clinical Nutrition Cross-Sectional Studies Density Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diet therapy Diabetes Mellitus, Type 1 - drug therapy Diet Diet, Mediterranean Epidemiology Feeding Behavior Female Follow-Up Studies Glucose metabolism Glycated Hemoglobin - metabolism Glycemic index Health aspects Health risk assessment Health risks Hemoglobin High density lipoprotein Humans Insulin - therapeutic use Internal Medicine Lipids Lipids - blood Lipoproteins - blood Low density lipoprotein Male Medicine Medicine & Public Health Metabolic Diseases Nutrition Nutrition research Obesity Observations original-article Patient Compliance Physiological aspects Public Health Regression models Risk analysis Risk Factors Risk management Teenagers Type 1 diabetes White People Young Adult Youth |
| title | Association of adherence to a Mediterranean diet with glycemic control and cardiovascular risk factors in youth with type I diabetes: the SEARCH Nutrition Ancillary Study |
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