Cerebellar cathodal tDCS interferes with recalibration and spatial realignment during prism adaptation procedure in healthy subjects

• Published in: Brain and cognition 2016-06, Vol.105, p.1-8
• Main Authors: Panico, Francesco, Sagliano, Laura, Grossi, Dario, Trojano, Luigi
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological - physiology; Adult; Cerebellum; Female; Flexibility; Healthy Volunteers; Humans; Male; Motor control; Prism adaptation; Psychomotor Performance - physiology; Space Perception - physiology; tDCS; Transcranial Direct Current Stimulation - methods; Visual Perception - physiology; Young Adult
• ISSN: 0278-2626; 1090-2147
• DOI: 10.1016/j.bandc.2016.03.002

•C-tDCS was used to assess cerebellar role in prism adaptation procedure.•Stimulation impaired adaptation to prisms and recovery from after-effect.•The cerebellum is involved in recalibration process and in spatial realignment. The aim of this study is to clarify the specific role of the cerebellum during prism adaptation procedure (PAP), considering its involvement in early prism exposure (i.e., in the recalibration process) and in post-exposure phase (i.e., in the after-effect, related to spatial realignment). For this purpose we interfered with cerebellar activity by means of cathodal transcranial direct current stimulation (tDCS), while young healthy individuals were asked to perform a pointing task on a touch screen before, during and after wearing base-left prism glasses. The distance from the target dot in each trial (in terms of pixels) on horizontal and vertical axes was recorded and served as an index of accuracy. Results on horizontal axis, that was shifted by prism glasses, revealed that participants who received cathodal stimulation showed increased rightward deviation from the actual position of the target while wearing prisms and a larger leftward deviation from the target after prisms removal. Results on vertical axis, in which no shift was induced, revealed a general trend in the two groups to improve accuracy through the different phases of the task, and a trend, more visible in cathodal stimulated participants, to worsen accuracy from the first to the last movements in each phase. Data on horizontal axis allow to confirm that the cerebellum is involved in all stages of PAP, contributing to early strategic recalibration process, as well as to spatial realignment. On vertical axis, the improving performance across the different stages of the task and the worsening accuracy within each task phase can be ascribed, respectively, to a learning process and to the task-related fatigue.