Evaluation of mean diffusion and kurtosis MRI mismatch in subacute ischemic stroke: comparison with NIHSS score

Abstract Neurological deterioration (ND) is a devastating complication following ischemic stroke. This study aimed to identify the differences in lesion characteristics in subacute ischemic stroke patients with and without ND using diffusional kurtosis imaging (DKI), as well as to confirm the respon...

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Bibliographic Details
Published in:Brain research 2016-08, Vol.1644, p.231-239
Main Authors: Guo, Yue-lin, Zhang, Zhong-ping, Zhang, Gui-shan, Kong, Ling-mei, Rao, Hai-bing, Chen, Wei, Wang, Guang-wen, Shen, Zhi-wei, Zheng, Wen-bin, Wu, Ren-hua
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brain - diagnostic imaging
Brain - pathology
Brain Ischemia - complications
Brain Ischemia - diagnostic imaging
Brain Ischemia - pathology
Data Interpretation, Statistical
Diagnosis, Computer-Assisted
Diffusion
Diffusion Magnetic Resonance Imaging - methods
Female
Humans
Ischemia
Kurtosis
Magnetic resonance imaging
Male
Middle Aged
Neurologic Examination
Neurology
NIHSS score
Severity of Illness Index
Stroke
Stroke - complications
Stroke - diagnostic imaging
Stroke - pathology
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Summary:Abstract Neurological deterioration (ND) is a devastating complication following ischemic stroke. This study aimed to identify the differences in lesion characteristics in subacute ischemic stroke patients with and without ND using diffusional kurtosis imaging (DKI), as well as to confirm the responsible lesions that may lead to ND, as assessed by the National Institutes of Health Stroke Scale (NIHSS) score. Seventy-nine patients with subacute cerebral infarction were allocated to the ND (–) and ND (+) groups according to the NIHSS score and lesion number. The mean diffusion (MD) lesions were significantly larger than the mean kurtosis (MK) deficits in the ND (+) group (P0.05). The MD and MK in the lesion recovered to normal levels over time; however, the recovery trends in the ND (+) group were substantially slower than the ND (–) group. The differences between the two groups were only significant regarding the MK (p
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2016.05.020