Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study from England

There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions.MethodsWe calculated...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2016-07, Vol.22 (7), p.1621-1630
Main Authors: Abdul Sultan, Alyshah, West, Joe, Ban, Lu, Humes, David, Tata, Laila J., Fleming, Kate M., Nelson-Piercy, Catherine, Card, Timothy
Format: Article
Language:English
Subjects:
Adolescent
Adult
Case-Control Studies
Cesarean Section - statistics & numerical data
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - surgery
Crohn Disease - epidemiology
Crohn Disease - surgery
England - epidemiology
Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Odds Ratio
Postpartum Hemorrhage - epidemiology
Pregnancy
Premature Birth - epidemiology
Prevalence
Young Adult
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Summary:There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions.MethodsWe calculated the proportion of pregnancies in women with and without IBD between 1997 and 2012 throughout England using linked primary (Clinical Practice Research Datalink) and secondary care (Hospital Episode Statistics) data. Risk of pregnancy-related complications and adverse birth outcomes in women with Crohn's disease and ulcerative colitis were compared with risks in women without IBD using odds ratios (ORs).ResultsOf 364,363 singleton pregnancies resulting in live or stillbirths, 1969 (0.5%) were in women with IBD. Women with Crohn's disease were more likely to have preterm births (OR = 1.42; 95% confidence interval, 1.12–1.79), babies with low birth weights (OR = 1.39; 95% confidence interval, 1.05–1.83), and postpartum hemorrhage (OR = 1.27; 95% confidence interval, 1.04–1.55), whereas women with ulcerative colitis were only at increased risk of preterm births with an absolute risk difference of
ISSN:1078-0998
1536-4844
DOI:10.1097/MIB.0000000000000802