Standardisation of uterine natural killer (uNK) cell measurements in the endometrium of women with recurrent reproductive failure

Highlights • There is variation in the numbers of endometrial uNK cell reported by different centres. • We have identified the factors which contribute to these differences. • Adoption of a standard protocol reduced the variation considerably. • Use of a single method is needed for measurements to h...

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Bibliographic Details
Published in:Journal of reproductive immunology 2016-08, Vol.116, p.50-59
Main Authors: Lash, Gendie E, Bulmer, Judith N, Li, Tin Chiu, Innes, Barbara A, Mariee, Najat, Patel, Gnyaneshwari, Sanderson, Jean, Quenby, Siobhan, Laird, Susan M
Format: Article
Language:English
Subjects:
Abortion, Habitual - diagnosis
Abortion, Habitual - immunology
Adult
Assessment protocol
CD56 Antigen - metabolism
Endometrium
Endometrium - pathology
Female
Humans
Immunohistochemistry
Killer Cells, Natural - immunology
Lymphocyte Count
Obstetrics and Gynecology
Paraffin Embedding
Pregnancy
Pregnancy Outcome
Recurrent implantation failure
Recurrent miscarriage
Reference Standards
Uterine natural killer cells
Uterus - pathology
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Summary:Highlights • There is variation in the numbers of endometrial uNK cell reported by different centres. • We have identified the factors which contribute to these differences. • Adoption of a standard protocol reduced the variation considerably. • Use of a single method is needed for measurements to have clinical significance.
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2016.04.290