Iron oxide nanoparticles as magnetic relaxation switching (MRSw) sensors: Current applications in nanomedicine

Abstract Since pioneering work in the early 60s on the development of enzyme electrodes the field of sensors has evolved to different sophisticated technological platforms. Still, for biomedical applications, there are key requirements to meet in order to get fast, low-cost, real-time data acquisiti...

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Bibliographic Details
Published in:Nanomedicine 2016-07, Vol.12 (5), p.1253-1262
Main Authors: Alcantara, David, PhD, Lopez, Soledad, PhD, García-Martin, María Luisa, PhD, Pozo, David, PhD
Format: Article
Language:English
Subjects:
Biosensing Techniques
Biosensors
Humans
Internal Medicine
Magnetic nanoparticles
Magnetic resonance
Magnetics
Nanodiagnostics
Nanoengineering
Nanomedical devices
Nanomedicine
Nanoparticles
Nanotechnology
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Summary:Abstract Since pioneering work in the early 60s on the development of enzyme electrodes the field of sensors has evolved to different sophisticated technological platforms. Still, for biomedical applications, there are key requirements to meet in order to get fast, low-cost, real-time data acquisition, multiplexed and automatic biosensors. Nano-based sensors are one of the most promising healthcare applications of nanotechnology, and prone to be one of the first to become a reality. From all nanosensors strategies developed, Magnetic Relaxation Switches (MRSw) assays combine several features which are attractive for nanomedical applications such as safe biocompatibility of magnetic nanoparticles, increased sensitivity/specificity measurements, possibility to detect analytes in opaque samples (unresponsive to light-based interferences) and the use of homogeneous setting assay. This review aims at presenting the ongoing progress of MRSw technology and its most important applications in clinical medicine.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2016.01.005