Probing vaccine antigens against bovine mastitis caused by Streptococcus uberis

Highlights • FBA and EFTs are promising candidates for a bovine mastitis vaccine against Streptococcus uberis. • FBA and EFTs confer partial protection in an intraperitoneal S. uberis infection in mice. • GAPDH, FBA and EFTs have been detected in both cytoplasm and cell wall fractions of S. uberis....

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Bibliographic Details
Published in:Vaccine 2016-07, Vol.34 (33), p.3848-3854
Main Authors: Collado, Rosa, Prenafeta, Antoni, González-González, Luis, Pérez-Pons, Josep Antoni, Sitjà, Marta
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Antigens
Antigens, Bacterial - immunology
Bacterial Vaccines - immunology
Biofilms
Cattle
Conflicts of interest
Dairy cattle
Dairy industry
Dehydrogenases
Electrophoresis, Gel, Two-Dimensional
Female
Fructose-Bisphosphatase - immunology
Gene Expression Regulation, Bacterial
Immune response
Immunization
Immunoglobulin G - blood
Immunology
Infections
Mastitis
Mastitis, Bovine - prevention & control
Mice
Mice, Inbred BALB C
Pathogens
Peptide Elongation Factors - immunology
Proteins
Proteomics
Rabbits
Recombinant Proteins - immunology
Streptococcal Infections - prevention & control
Streptococcal Infections - veterinary
Streptococcus
Streptococcus uberis
Vaccine
Vaccines
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Summary:Highlights • FBA and EFTs are promising candidates for a bovine mastitis vaccine against Streptococcus uberis. • FBA and EFTs confer partial protection in an intraperitoneal S. uberis infection in mice. • GAPDH, FBA and EFTs have been detected in both cytoplasm and cell wall fractions of S. uberis.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.05.044