Multiple endocrine neoplasia syndromes 1 and 2: manifestations and management in childhood and adolescence

The identification of the genetic causes of the multiple endocrine neoplasia (MEN) syndromes 1 and 2, and associated genotype–phenotype relationships, has revolutionised the clinical care of affected patients. A genetic diagnosis can be made during infancy and careful clinical surveillance, coupled...

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Bibliographic Details
Published in:Archives of disease in childhood 2015-10, Vol.100 (10), p.994-999
Main Authors: Giri, D, McKay, V, Weber, A, Blair, JC
Format: Article
Language:English
Subjects:
Adenomatosis, Familial endocrine
Adolescent
Adolescents
Analysis
Care and treatment
Child
Children
Clinical Diagnosis
Diagnosis
Family (Sociological Unit)
Genetic Testing
Health aspects
Humans
Multiple endocrine neoplasia
Multiple Endocrine Neoplasia - diagnosis
Multiple Endocrine Neoplasia - genetics
Multiple Endocrine Neoplasia - therapy
Mutation
Patients
Risk factors
Sentinel health events
Sentinel surveillance
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Description
Summary:The identification of the genetic causes of the multiple endocrine neoplasia (MEN) syndromes 1 and 2, and associated genotype–phenotype relationships, has revolutionised the clinical care of affected patients. A genetic diagnosis can be made during infancy and careful clinical surveillance, coupled with early intervention, has the potential to improve both morbidity and mortality. These developments have seen the management of patients with MEN move into the arena of paediatric medicine. In this review article, we consider the genetic causes of MEN together with the clinical manifestations and management of these syndromes.
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2014-307028