Anti-NMDAR antibodies in new-onset psychosis. Positive results in an HIV-infected patient

Highlights • Neuronal surface antibodies (NSAs) were tested in 61 new-onset psychosis patients. • A positive case for NASs in a non-encephalitic psychosis is reported. • The case was positive for antibodies against the NR1 subunit of NMDAR. • The patient was HIV-positive and met the DSM-IVR criteria...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.56-60
Main Authors: Arboleya, Susana, Clemente, Antonio, Deng, Savannah, Bedmar, Marta, Salvador, Isabel, Herbera, Patricia, Cunill, Vanessa, Vives-Bauza, Cristòfol, Haro, Josep Maria, Canellas, Francesca, Julià, Maria Rosa
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Antigens, Surface - immunology
Autoantibodies - blood
Autoimmunity
Bipolar Disorder - immunology
Encephalitis
Female
HIV
HIV Seropositivity - immunology
Human immunodeficiency virus
Humans
Lentivirus
Male
Mania
NMDAR
Psychiatry
Psychosis
Psychotic Disorders - immunology
Receptors, N-Methyl-D-Aspartate - immunology
Retroviridae
Schizophrenia
Young Adult
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Summary:Highlights • Neuronal surface antibodies (NSAs) were tested in 61 new-onset psychosis patients. • A positive case for NASs in a non-encephalitic psychosis is reported. • The case was positive for antibodies against the NR1 subunit of NMDAR. • The patient was HIV-positive and met the DSM-IVR criteria for bipolar I disorder. • NSAs role in psychiatric symptoms of HIV-infected patients should be considered.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.03.011