Associations of low grade inflammation and endothelial dysfunction with depression - The Maastricht Study

Highlights • hsCRP, TNF-α, SAA, sICAM-1, sE-Selectin were univariate associated with depression. • sum score of inflammation was associated with depression, also after adjustments. • sum score of endothelial dysfunction was associated with depressive disorder. • sum score of endothelial dysfunction...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.390-396
Main Authors: van Dooren, Fleur E.P, Schram, Miranda T, Schalkwijk, Casper G, Stehouwer, Coen D.A, Henry, Ronald M.A, Dagnelie, Pieter C, Schaper, Nicolaas C, van der Kallen, Carla J.H, Koster, Annemarie, Sep, Simone J.S, Denollet, Johan, Verhey, Frans R.J, Pouwer, Frans
Format: Article
Language:English
Subjects:
Aged
Allergy and Immunology
Biomarkers - blood
Cohort Studies
Depression
Depression - blood
Depression - epidemiology
Depressive Disorder - blood
Depressive Disorder - epidemiology
Endothelial dysfunction
Endothelium, Vascular - physiopathology
Female
Humans
Inflammation
Inflammation - blood
Inflammation - epidemiology
Lifestyle factors
Male
Middle Aged
Netherlands - epidemiology
Psychiatry
Vascular Diseases - blood
Vascular Diseases - epidemiology
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Summary:Highlights • hsCRP, TNF-α, SAA, sICAM-1, sE-Selectin were univariate associated with depression. • sum score of inflammation was associated with depression, also after adjustments. • sum score of endothelial dysfunction was associated with depressive disorder. • sum score of endothelial dysfunction was not associated with depressive symptoms.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.03.004