Exposure to widespread environmental endocrine disrupting chemicals and human sperm sex ratio

In recent years, a trend toward a declining proportion of male births has been noted in several, but not all, industrialized countries. The underlying reason for the drop in the sex ratio is unclear, but one theory states that widespread environmental endocrine disrupting chemicals affecting the mal...

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Bibliographic Details
Published in:Environmental pollution (1987) 2016-06, Vol.213, p.732-740
Main Authors: Jurewicz, Joanna, Radwan, Michał, Sobala, Wojciech, Radwan, Paweł, Jakubowski, Lucjusz, Wielgomas, Bartosz, Ligocka, Danuta, Brzeźnicki, Sławomir, Hanke, Wojciech
Format: Article
Language:English
Subjects:
Adult
Endocrine Disruptors - toxicity
Environmental Exposure
Environmental Pollutants - toxicity
Humans
Male
Phthalates
Phthalic Acids - urine
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - urine
Pyrenes - urine
Pyrethrins - urine
Semen
Sex Ratio
Sperm Count
Spermatozoa
Synthetic pyrethroids
Young Adult
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Summary:In recent years, a trend toward a declining proportion of male births has been noted in several, but not all, industrialized countries. The underlying reason for the drop in the sex ratio is unclear, but one theory states that widespread environmental endocrine disrupting chemicals affecting the male reproductive system in a negative manner could be part of the explanation. The present study was designed to investigate whether the urinary phthalate, pyrethroids and polycyclic aromatic hydrocarbons metabolites concentrations were associated with sperm Y:X ratio. The study population consisted of 194 men aged under 45 years of age who attended infertility clinic in Lodz, Poland for diagnostic purposes with normal semen concentration of 20–300 mln/ml or with slight oligozoospermia (semen concentration of 15–20 mln/ml) (WHO, 1999). The Y:X ratio was assessed by fluorescent in situ hybridization. Urinary concentrations of 1-hydroxypyrene were measured by high performance liquid chromatography, phthalate metabolites were analyzed using a procedure based on the LC-MS/MS methods and metabolites of synthetic pyrethroids were assessed by gas chromatography ion-tap mass spectrometry method. After adjustment for potential confounders (past diseases, age, abstinence, smoking, alcohol consumption, sperm concentration, motility, morphology) 5OH MEHP, CDCCA to TDCCA and 1-OHP was negatively related to Y:X sperm chromosome ratio (p = 0.033, p 
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2016.02.008