mRNA-based therapeutics–Advances and perspectives

In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo . Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2016-07, Vol.81 (7), p.709-722
Main Authors: Sergeeva, O. V., Koteliansky, V. E., Zatsepin, T. S.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cancer immunotherapy
Clinical trials
Drug Carriers - chemistry
Humans
Immune response
Immune system
Immunity, Innate
Immunotherapy
Infectious diseases
Life Sciences
Lipids
Liposomes - chemistry
Microbiology
Nanoparticles
Nanoparticles - chemistry
Neoplasms - immunology
Neoplasms - therapy
Polymers
Review
RNA, Messenger - chemistry
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcription
Vaccination
Vaccines
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Description
Summary:In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo . Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297916070075