Postoperative prognostic nutritional index change is an independent predictor of survival in patients with small hepatocellular carcinoma

Abstract Background There is limited information concerning the postoperative prognostic nutritional index change (ΔPNI) in hepatocellular carcinoma (HCC). This study was designed to evaluate the prognostic value of ΔPNI in patients with small HCC who underwent liver resection. Methods A retrospecti...

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Bibliographic Details
Published in:The American journal of surgery 2016-07, Vol.212 (1), p.122-127
Main Authors: Peng, Wei, M.D, Li, Chuan, M.D, Wen, Tian-Fu, M.D, Yan, Lv-Nan, M.D, Li, Bo, M.D, Wang, Wen-Tao, M.D, Yang, Jia-Yin, M.D, Xu, Ming-Qing, M.D
Format: Article
Language:English
Subjects:
Adult
Aged
Blood
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
China
Cohort Studies
Confidence intervals
Disease-Free Survival
Female
Females
Hepatectomy - methods
Hepatectomy - mortality
Hepatitis
Hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver cancer
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver resection
Logistic Models
Male
Medical prognosis
Middle Aged
Milan criteria
Multivariate Analysis
Nutrition Assessment
Postoperative Period
Predictive Value of Tests
Prognosis
Prognostic factor
Prognostic nutritional index
Proportional Hazards Models
Retrospective Studies
Statistical analysis
Surgery
Survival Analysis
Treatment Outcome
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Summary:Abstract Background There is limited information concerning the postoperative prognostic nutritional index change (ΔPNI) in hepatocellular carcinoma (HCC). This study was designed to evaluate the prognostic value of ΔPNI in patients with small HCC who underwent liver resection. Methods A retrospective cohort study was performed to analyze 243 patients with small HCC who underwent liver resection. Patients were divided into prognostic nutritional index (PNI)–increased group (n = 161) and PNI-decreased group (n = 82) according to postoperative PNI change. Clinical data, overall survival (OS), and recurrence-free survival (RFS) were statistically compared between the 2 groups, and a multivariate analysis was used to identify prognostic factors. Results Multivariable analysis revealed that ΔPNI as independent predictors of OS and RFS in patients with small HCC after liver resection ( P < .01 for both). Conclusions Decreased PNI, but not low preoperative PNI was an independent risk factor for OS and RFS in patients with small HCC who underwent liver resection.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2015.06.023