Patterns and reliability of EEG during error monitoring for internal versus external feedback in schizophrenia

• Published in: International journal of psychophysiology 2016-07, Vol.105, p.39-46
• Main Authors: Llerena, Katiah, Wynn, Jonathan K., Hajcak, Greg, Green, Michael F., Horan, William P.
• Format: Article
• Language: English
• Subjects: Adult; Brain Mapping; Contingent Negative Variation - physiology; Electroencephalography; Event related potentials; Feedback; Female; Humans; Male; Middle Aged; Performance monitoring; Photic Stimulation; Principal Component Analysis; Psychiatric Status Rating Scales; Psychomotor Performance - physiology; Reaction Time - physiology; Reproducibility of Results; Reward; Schizophrenia; Schizophrenia - physiopathology; Schizophrenic Psychology; Time Perception - physiology
• ISSN: 0167-8760; 1872-7697
• DOI: 10.1016/j.ijpsycho.2016.04.012

Accurately monitoring one's performance on daily life tasks, and integrating internal and external performance feedback are necessary for guiding productive behavior. Although internal feedback processing, as indexed by the error-related negativity (ERN), is consistently impaired in schizophrenia, initial findings suggest that external performance feedback processing, as indexed by the feedback negativity (FN), may actually be intact. The current study evaluated internal and external feedback processing task performance and test-retest reliability in schizophrenia. 92 schizophrenia outpatients and 63 healthy controls completed a flanker task (ERN) and a time estimation task (FN). Analyses examined the ΔERN and ΔFN defined as difference waves between correct/positive versus error/negative feedback conditions. A temporal principal component analysis was conducted to distinguish the ΔERN and ΔFN from overlapping neural responses. We also assessed test-retest reliability of ΔERN and ΔFN in patients over a 4-week interval. Patients showed reduced ΔERN accompanied by intact ΔFN. In patients, test-retest reliability for both ΔERN and ΔFN over a four-week period was fair to good. Individuals with schizophrenia show a pattern of impaired internal, but intact external, feedback processing. This pattern has implications for understanding the nature and neural correlates of impaired feedback processing in schizophrenia. •Schizophrenia patients show deficient early internal feedback monitoring, but intact external performance feedback monitoring.•The test-retest reliability of internal and external performance feedback indices was in the fair to good range.•Internal feedback monitoring deficits and intact external feedback monitoring may reflect distinct neural generators.