Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases

The prognosis of autoimmune thyroid diseases (AITDs), including Graves’ disease (GD) and Hashimoto’s disease (HD), varies among patients. Inducible co-stimulator (ICOS) (CD278) and co-stimulator ligand (ICOSL) (CD275) are important costimulatory molecules. Their interactions play important roles in...

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Bibliographic Details
Published in:Endocrine Journal 2016, Vol.63(1), pp.61-68
Main Authors: Yoshie, Namiki, Watanabe, Mikio, Inoue, Naoya, Kawaguchi, Hayaka, Hidaka, Yoh, Iwatani, Yoshinori
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Case-Control Studies
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
ICOS
ICOSL
Inducible T-Cell Co-Stimulator Ligand - genetics
Inducible T-Cell Co-Stimulator Protein - genetics
Intractability
Male
Middle Aged
Polymorphism, Single Nucleotide
Severity
Single-nucleotide polymorphism
Thyroiditis, Autoimmune - epidemiology
Thyroiditis, Autoimmune - genetics
Young Adult
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Summary:The prognosis of autoimmune thyroid diseases (AITDs), including Graves’ disease (GD) and Hashimoto’s disease (HD), varies among patients. Inducible co-stimulator (ICOS) (CD278) and co-stimulator ligand (ICOSL) (CD275) are important costimulatory molecules. Their interactions play important roles in immune regulation and the pathogenesis of autoimmune diseases through tuning T cell activation, differentiation and function. To clarify the association between ICOS-ICOSL signals and AITD, we genotyped single-nucleotide polymorphism (SNP)1 and SNP2 in the ICOS gene and SNP1, SNP2 and SNP3 in the ICOSL gene in 239 HD patients, 232 GD patients, and 129 healthy volunteers (control subjects). There were no differences in genotype and allele frequencies among the three groups, although the frequencies of the AA genotype and A allele of ICOSL SNP2 (rs15927) were slightly, but not significantly, higher in patients with GD, intractable GD, and severe HD than in controls. The mRNA levels of ICOSL were also slightly, but not significantly, lower in individuals with the AA genotype of ICOSL SNP2 than in those with the AG+GG genotypes. In conclusion, the ICOS and ICOSL SNPs examined in this study do not have an apparent effect on the disease susceptibility and prognosis of AITDs.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ15-0435