Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation

Summary Antigen presentation refers to the ability of cells to show MHC‐associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide‐derived antigens that are internalized by endocytosis in antigen‐presenting cells (APCs). Here, we describe how...

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Bibliographic Details
Published in:Immunological reviews 2016-07, Vol.272 (1), p.39-51
Main Authors: Bretou, Marine, Kumari, Anita, Malbec, Odile, Moreau, Hélène D., Obino, Dorian, Pierobon, Paolo, Randrian, Violaine, Sáez, Pablo J., Lennon-Duménil, Ana-Maria
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation
Antigen-presenting cells
Antigens
Antigens - metabolism
B lymphocyte
B-Lymphocytes - immunology
Cell activation
Cell adhesion & migration
Cell interactions
Cell Membrane - metabolism
Cell Movement
cell polarity
Cytoskeleton
Cytoskeleton - metabolism
dendritic cell
Dendritic cells
Dendritic Cells - immunology
Endocytosis
Histocompatibility Antigens - metabolism
Humans
Immunological Synapses
Leukocyte migration
Lymphocyte Activation
Lymphocytes
Lymphocytes B
Lymphocytes T
Major histocompatibility complex
membrane trafficking
Membranes
Molecular chains
Peptides - metabolism
T-Lymphocytes - immunology
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Summary:Summary Antigen presentation refers to the ability of cells to show MHC‐associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide‐derived antigens that are internalized by endocytosis in antigen‐presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC–T cell interactions. We further discuss how the interaction between APC‐specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.
ISSN:0105-2896
1600-065X
DOI:10.1111/imr.12429