Effect of Hepatitis C Positivity on Survival in Adult Patients Undergoing Heart Transplantation (from the United Network for Organ Sharing Database)

Concerns exist regarding orthotropic heart transplantation in hepatitis C virus (HCV) seropositive recipients. Thus, a national registry was accessed to evaluate early and late outcome in HCV seropositive recipients undergoing heart transplant. Retrospective analysis of the United Network for Organ...

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Bibliographic Details
Published in:The American journal of cardiology 2016-07, Vol.118 (1), p.132-137
Main Authors: Kumar, Sachin, MD, Deo, Salil V., MD, Altarabsheh, Salah E., MD, Dunlay, Shannon M., MD, MS, Sarabu, Nagaraju, MD, MPH, Sareyyupoglu, Basar, MD, Elgudin, Yakov, MD, Medalion, Benjamin, MD, ElAmm, Chantal, MD, Ginwalla, Mahazarin, MD, Zacharias, Michael, MD, Benatti, Rodolpho, MD, Oliveira, Guilherme H., MD, Kilic, Ahmet, MD, Fonarow, Gregg C., MD, Park, Soon J., MD
Format: Article
Language:English
Subjects:
Adult
Age
Alcohol
Antigens
Blood groups
Cardiomyopathy
Cardiovascular
Cocaine
Cytomegalovirus
Diabetes
Female
Graft Survival
Heart failure
Heart Failure - mortality
Heart Failure - surgery
Heart Failure - virology
Heart Transplantation
Hepatitis
Hepatitis B virus
Hepatitis C - complications
Hepatitis C virus
Humans
Male
Middle Aged
Mortality
Patients
Postoperative period
Registries
Retrospective Studies
Survival Rate
Transplants & implants
Treatment Outcome
United States
Variables
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Summary:Concerns exist regarding orthotropic heart transplantation in hepatitis C virus (HCV) seropositive recipients. Thus, a national registry was accessed to evaluate early and late outcome in HCV seropositive recipients undergoing heart transplant. Retrospective analysis of the United Network for Organ Sharing registry (1991 to 2014) was performed to evaluate recipient profile and clinical outcome of patients with HCV seropositive (HCV +ve) and seronegative (HCV −ve). Adjusted results of early mortality and late survival were compared between cohorts. From 23,507 patients (mean age 52 years; 75% men), 481 (2%) were HCV +ve (mean age 52 years; 77% men). Annual proportion of HCV +ve recipients was comparable over the study period (range 1.3% to 2.7%; p = 0.2). The HCV +ve cohort had more African-American (22% vs 17%; p = 0.01), previous left ventricular assist device utilization (21% vs 14%; p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.04.023