Comparison of bone morphogenetic protein-2 delivery systems to induce supracrestal bone guided by titanium implants in the rabbit mandible

Objective To compare the ability of three non‐glycosylated/rhBMP‐2 (BMP‐2) delivery systems to induce supracrestal bone. Material and methods Thirty‐six custom SLActive dental implants were partially embedded in transverse orientation into the posterior mandibles of 18 adult rabbits with the head of...

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Bibliographic Details
Published in:Clinical oral implants research 2016-06, Vol.27 (6), p.676-685
Main Authors: Wen, Bo, Kuhn, Liisa, Charles, Lyndon, Pendrys, David, Shafer, David, Freilich, Martin
Format: Article
Language:English
Subjects:
Animals
biomaterial scaffold
BMP-2
Bone Morphogenetic Protein 2 - administration & dosage
Bone Morphogenetic Protein 2 - pharmacology
Calcium Phosphates - pharmacology
Collagen - pharmacology
dental implant
Dental Implants
Dentistry
Drug Delivery Systems
Durapatite - pharmacology
Hydrogels - pharmacology
Mandible - surgery
Osteogenesis - drug effects
Polyethylene Glycols - pharmacology
Rabbits
Tissue Scaffolds
Titanium
vertical supracrestal bone growth
X-Ray Microtomography
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Summary:Objective To compare the ability of three non‐glycosylated/rhBMP‐2 (BMP‐2) delivery systems to induce supracrestal bone. Material and methods Thirty‐six custom SLActive dental implants were partially embedded in transverse orientation into the posterior mandibles of 18 adult rabbits with the head of the implant located 3 mm supracrestal. Delivery of BMP‐2 (30 μg) from the following materials was studied: (1) Ti implant + BMP‐2 with hydroxyapatite (HA)‐coated collagen (Col/HA) scaffold, (2) Ti implant with Col/HA infused with PEG hydrogel + BMP‐2, or (3) Ti implant with HA/β‐TCP/PEG hydrogel scaffold + BMP‐2. Scaffolds were secured with a metal “umbrella.” Non‐BMP‐2 contralateral controls were included. MicroCT imaging and histological analysis was performed after 10 weeks to assess new supracrestal bone formation. In vitro BMP‐2 release studies were conducted. Results All treatment groups displayed new supracrestal bone formation. Ti + BMP‐2 with Col/HA (3.0 ± 0.2 mm) and Ti with Col/HA/PEG hydrogel + BMP‐2 (2.7 ± 0.4 mm) had significantly greater (P 
ISSN:0905-7161
1600-0501
DOI:10.1111/clr.12645