Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice

The aim of the present study was to investigate the protective effects of curcumin alone and in combination with piperine against lipopolysaccharide (LPS)-induced neurobehavioral and neurochemical deficits in the mice hippocampus. Mice were treated with curcumin (100, 200, and 400 mg/kg, p.o.) and p...

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Bibliographic Details
Published in:Inflammation 2016-06, Vol.39 (3), p.1025-1038
Main Authors: Jangra, Ashok, Kwatra, Mohit, Singh, Tavleen, Pant, Rajat, Kushwah, Pawan, Sharma, Yogita, Saroha, Babita, Datusalia, Ashok Kumar, Bezbaruah, Babul Kumar
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Alkaloids - therapeutic use
Animals
Benzodioxoles - pharmacology
Benzodioxoles - therapeutic use
Biomedical and Life Sciences
Biomedicine
Curcumin - pharmacology
Curcumin - therapeutic use
Drug Synergism
Hippocampus - drug effects
Hippocampus - pathology
Immunology
Internal Medicine
Lipopolysaccharides
Mice
Neurodegenerative Diseases - drug therapy
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Original Article
Pathology
Pharmacology/Toxicology
Piperidines - pharmacology
Piperidines - therapeutic use
Polyunsaturated Alkamides - pharmacology
Polyunsaturated Alkamides - therapeutic use
Rheumatology
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Summary:The aim of the present study was to investigate the protective effects of curcumin alone and in combination with piperine against lipopolysaccharide (LPS)-induced neurobehavioral and neurochemical deficits in the mice hippocampus. Mice were treated with curcumin (100, 200, and 400 mg/kg, p.o.) and piperine (20 mg/kg, p.o.) for 7 days followed by LPS (0.83 mg/kg, i.p.) administration. Animals exhibited anxiety and depressive-like phenotype after 3 and 24 h of LPS exposure, respectively. LPS administration increased the oxido-nitrosative stress as evident by elevated levels of malondialdehyde, nitrite, and depletion of glutathione level in the hippocampus. Furthermore, we found raised level of pro-inflammatory cytokines (IL-1β and TNF-α) in the hippocampus of LPS-treated mice. Pretreatment with curcumin alleviated LPS-induced neurobehavioral and neurochemical deficits. Furthermore, co-administration of curcumin with piperine significantly potentiated the neuroprotective effect of curcumin. These results demonstrate that piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-016-0332-4