PS-077The Implication Of Il-6 572 C/g Gene Polymorphisms In Children's Malnutrition

• Published in: Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A139-A140
• Main Authors: Marginean, O, Chincesan, M, Marginean, M, Marginean, C
• Format: Article
• Language: English
• ISSN: 0003-9888
• DOI: 10.1136/archdischild-2014-307384.374

Malnutrition is a disorder caused by reducing the energetical and/or protein input, with adverse effects on tissue and body form and function and different clinical consequences.AimThe aim of this study was to establish the correlations between the polymorphisms of the IL-6 572 gene in malnourished children.MethodsWe assessed 283 hospitalised children divided into two groups: group I (control) included 110 patients with normal nutritional status, and group II consisted of 173 malnourished patients.The two groups underwent IL-6 572 C/G polymorphism testing, measurement of anthropometric parameters (mid-upper arm circumference, MUAC and tricipital skinfold thickness, TST), and paraclinical evaluation (protein, albumin).ResultsWe observed that the differences between the anthropometric parameters (MUAC and TST) corresponding to the three types of genotypes (CC, CG, GG) were statistically significant lower in malnourished children with all the three genotype of IL-6 572 (p = 0.0001). Same correlations were noticed with low serum albumin levels.ConclusionIn children with malnutrition BMI, MUAC, TST and low serum albumin levels correlated with genotype GG and CG of the IL-6 572 gene.