The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients

Abstract Background A complete biochemical response (BR) immediately after surgery could be considered an indicator of optimal cancer control after radical prostatectomy (RP). Objective To evaluate the prognostic value of early postoperative prostate-specific antigen (PSA) levels after RP in patient...

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Published in:European urology 2016-06, Vol.69 (6), p.1142-1148
Main Authors: Bianchi, Lorenzo, Nini, Alessandro, Bianchi, Marco, Gandaglia, Giorgio, Fossati, Nicola, Suardi, Nazareno, Moschini, Marco, Dell’Oglio, Paolo, Schiavina, Riccardo, Montorsi, Francesco, Briganti, Alberto
Format: Article
Language:English
Subjects:
Aged
Androgen Antagonists - therapeutic use
Biochemical response
Cancer-specific mortality
Chemoradiotherapy, Adjuvant
Chemotherapy, Adjuvant
Clinical recurrence
Disease Progression
Humans
Kaplan-Meier Estimate
Lymph node invasion
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Margins of Excision
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local - blood
Neoplasm Staging
Postoperative Period
Predictive Value of Tests
Proportional Hazards Models
Prostate cancer
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Neoplasms - blood
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
PSA persistence
Radical prostatectomy
Retrospective Studies
Urology
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Summary:Abstract Background A complete biochemical response (BR) immediately after surgery could be considered an indicator of optimal cancer control after radical prostatectomy (RP). Objective To evaluate the prognostic value of early postoperative prostate-specific antigen (PSA) levels after RP in patients with lymph node invasion (LNI). Design, setting, and participants The study included 319 prostate cancer patients with LNI who were treated with RP and extended pelvic lymph node dissection (ePLND) at a single institution between 1998 and 2013. All men had complete clinical, pathologic, and follow-up data, including PSA value at 6 wk after surgery. Patients were divided into two groups according to PSA value at 6 wk after surgery: complete BR (PSA
ISSN:0302-2838
1873-7560
DOI:10.1016/j.eururo.2015.12.010