Effect of heat stress on performance and expression of selected amino acid and glucose transporters, HSP90, leptin and ghrelin in growing pigs

Exposing animals to high ambient temperature provokes heat stress (HS) that may affect cellular function and reduced productive performance. The effect of chronic exposure (21d) of pigs to high ambient temperature on expression of amino acid (b0,+AT, CAT1) and glucose (SGLT1, GLUT4) transporters, gh...

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Published in:Journal of thermal biology 2016-07, Vol.59, p.69-76
Main Authors: Cervantes, Miguel, Cota, Margarita, Arce, Néstor, Castillo, Gilberto, Avelar, Ernesto, Espinoza, Salvador, Morales, Adriana
Format: Article
Language:English
Subjects:
Acclimatization
air conditioning
ambient temperature
Amino Acid Transport Systems - genetics
amino acids
Animals
b0,+AT
Body Temperature
body weight
CAT1
Cationic Amino Acid Transporter 1 - genetics
chronic exposure
duodenum
feed conversion
feed intake
Gene Expression Regulation
ghrelin
Ghrelin - genetics
glucose
Glucose Transporter Type 4 - genetics
glucose transporters
GLUT4
Heat stress
Heat-Shock Response
Hot Temperature
HSP90
HSP90 Heat-Shock Proteins - genetics
Humidity
jejunum
leptin
Leptin - genetics
liver
messenger RNA
mRNA
muscles
Nutrient transporter
Pig
Respiration
respiratory rate
SGLT1
Sodium-Glucose Transporter 1 - genetics
stomach
swine
Swine - genetics
Swine - growth & development
Swine - physiology
TNad
TNpf
weight gain
white adipose tissue
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Summary:Exposing animals to high ambient temperature provokes heat stress (HS) that may affect cellular function and reduced productive performance. The effect of chronic exposure (21d) of pigs to high ambient temperature on expression of amino acid (b0,+AT, CAT1) and glucose (SGLT1, GLUT4) transporters, ghrelin, leptin and HSP90 was evaluated. Eighteen pigs (32.6kg body weight) were distributed into 3 groups: (1) pigs housed under natural high ambient temperature conditions, and fed ad libitum (HS); (2) pigs housed in an air-conditioned room at 24°C (thermo-neutral) fed ad libitum (TNad); (3) pigs housed as in (2), but pair-fed with the HS pigs (TNpf). Body temperature, respiratory frequency, weight gain, feed intake, and feed conversion ratio were measured. At d-21 pigs were euthanized and samples from stomach, duodenum, jejunum, liver, longissimus and semitendinosus muscles, and white adipose tissue were collected for mRNA analysis. In the HS room ambient temperature fluctuated every day (23.6–37.6°C). Respiratory frequency and body temperature were higher in HS pigs (P
ISSN:0306-4565
1879-0992
DOI:10.1016/j.jtherbio.2016.04.014