Drug-resistant focal epilepsy in women of childbearing age: Reproduction and the effect of epilepsy surgery

• Published in: Epilepsy & behavior 2016-07, Vol.60, p.17-20
• Main Authors: Fabris, Rachel R, Cascino, Teresa Griffin, Mandrekar, Jay, Marsh, W. Richard, Meyer, Frederic B, Cascino, Gregory D
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anticonvulsants - adverse effects; Anticonvulsants - therapeutic use; Cerebral Cortex - surgery; Drug Resistant Epilepsy - complications; Drug Resistant Epilepsy - surgery; Drug-resistant focal epilepsy; Female; Focal cortical resection; Follow-Up Studies; Humans; Infertility, Female - complications; Middle Aged; Neurology; Neurosurgical Procedures; Pregnancy; Reproduction; Retrospective Studies; Socioeconomic Factors; Treatment Outcome; Women; Women with epilepsy; Young Adult
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2016.04.002

Abstract Objective Women with epilepsy (WWE) have lower birth rates than expected. The reasons for this are multifactorial and involve a complex interaction between reproductive endocrine and psychosocial factors. The effect of epilepsy surgery on reproduction in women with drug-resistant focal epilepsy has not previously been studied. Methods Adult women of childbearing age (18–45 years old) with drug-resistant focal epilepsy who had undergone a focal cortical resection between 1997 and 2008 at the Mayo Clinic in Rochester, MN were included in the study. Patients who had a history of hysterectomy or tubal ligation or who were menopausal at the time of surgery were excluded. Data on prior pregnancies and births, epilepsy history, surgical treatment, hormonal dysfunction, and socioeconomic status were obtained using a retrospective chart review. Associations between various clinical and demographic variables with changes in pregnancies and births from pre- to postsurgery were assessed using Chi-square or Fisher's exact test for categorical variables and Wilcoxon rank sum test for continuous variables. All tests were 2-sided, and p-values less than 0.05 were considered statistically significant. All analyses were performed using SAS software version 9.2 (SAS INC, Cary NC). Results One hundred and thirteen women (average age: 30.5 years) were included in the study. Average length of follow-up was 5.7 years (SD-3.90). Sixty-four patients (57.5%) were nulliparous at the time of surgery. Sixty-one patients (54%) had never been married. Average number of pregnancies per patient prior to surgery was 0.93, and average number of births prior to surgery was 0.73. After surgery, a total of 17 women had a total of 35 pregnancies and 25 births. The average number of pregnancies and births after surgery was 1.27 and 0.96, respectively. Infertility was reported in one patient postoperatively. Patients who were younger at the time of surgery experienced a greater change in the number of pregnancies and births after surgery (p = 0.0036 and 0.0060, respectively). Patients who received fewer antiepileptic drug medication trials by the time of surgery also had a greater change in the number of births after surgery (p = 0.0362). Seizure onset localization and lateralization, presurgical seizure frequency, age at seizure onset, duration of epilepsy, and postoperative seizure outcome were not statistically significant factors. Conclusion The present retrospective observational st