Microwave-assisted Synthesis and antifungal activity of coumarin[8,7-e][1,3]oxazine derivatives

The synthesis of novel coumarin[8,7- e ][1,3]oxazine derivatives through a microwave-assisted three-component one-pot Mannich reaction is described in this study. All the target compounds were evaluated in vitro for their antifungal activity against Botrytis cinerea , Colletotrichum capsici , Altern...

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Bibliographic Details
Published in:Molecular diversity 2016-08, Vol.20 (3), p.611-618
Main Authors: Zhang, Ming-Zhi, Zhang, Rong-Rong, Yin, Wen-Zheng, Yu, Xiang, Zhang, Ya-Ling, Liu, Pin, Gu, Yu-Cheng, Zhang, Wei-Hua
Format: Article
Language:English
Subjects:
Alternaria
Alternaria solani
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial agents
Biochemistry
Biomedical and Life Sciences
Botrytis cinerea
Chemical compounds
Chemical reactions
Chemical synthesis
Colletotrichum
Combinatorial Chemistry Techniques
Coumarins - chemistry
Fungi - drug effects
Gibberella zeae
Life Sciences
Microwave heating
Microwaves
Molecular Structure
Organic Chemistry
Original Article
Oxazines - chemical synthesis
Oxazines - chemistry
Oxazines - pharmacology
Pharmacy
Polymer Sciences
Rhizoctonia solani
Structure-Activity Relationship
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Summary:The synthesis of novel coumarin[8,7- e ][1,3]oxazine derivatives through a microwave-assisted three-component one-pot Mannich reaction is described in this study. All the target compounds were evaluated in vitro for their antifungal activity against Botrytis cinerea , Colletotrichum capsici , Alternaria solani , Gibberella zeae , Rhizoctonia solani , and Alternaria mali . The preliminary bioassays showed that 5e , 5m , and 5s exhibited good antifungal activity and the most active compound was 5m with an EC 50 value as low as 2.1 nM against Botrytis cinerea .
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-016-9662-2