Staying local — antigen presentation in the liver

Highlights • The liver has unique immune functions. • Organ-resident cells contribute to regulation of antigen-specific immunity by functioning as antigen-presenting cells. • Different liver antigen presenting cell populations induce distinct functional programing of T cells. • Local antigen present...

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Bibliographic Details
Published in:Current opinion in immunology 2016-06, Vol.40, p.36-42
Main Author: Knolle, Percy A
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigen Presentation
Antigen-Presenting Cells - immunology
CD8-Positive T-Lymphocytes - immunology
Cellular Microenvironment - immunology
Hepatocytes - physiology
Humans
Immune Tolerance
Immunologic Memory
Immunologic Surveillance
Liver - immunology
Liver - pathology
Lymphocyte Activation
T-Lymphocytes, Regulatory - physiology
Virus Diseases - immunology
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Summary:Highlights • The liver has unique immune functions. • Organ-resident cells contribute to regulation of antigen-specific immunity by functioning as antigen-presenting cells. • Different liver antigen presenting cell populations induce distinct functional programing of T cells. • Local antigen presentation in the liver contributes to regulation of systemic immunity and functions in immune surveillance against viral infection of hepatocytes.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2016.02.009