General health status and intelligence scores of children of mothers with acromegaly do not differ from those of healthy mothers

• Published in: Pituitary 2016-08, Vol.19 (4), p.391-398
• Main Authors: Haliloglu, Ozlem, Dogangun, Burak, Ozcabi, Bahar, Kural, Hanife Ugur, Keskin, Fatma Ela, Ozkaya, Hande Mefkure, Pamukcu, Fatma Colkesen, Bektas, Elif, Poyraz, Burc Cagri, Buber, Hakan, Evliyaoglu, Olcay, Kadioglu, Pinar
• Format: Article
• Language: English
• Subjects: Adenoma - epidemiology; Adolescent; Case-Control Studies; Child; Child, Preschool; Endocrinology; Female; Fetal Macrosomia - epidemiology; Growth Hormone-Secreting Pituitary Adenoma - epidemiology; Health Status; Human Physiology; Humans; Hypoglycemia - epidemiology; Infant; Infant, Newborn; Infant, Newborn, Diseases - epidemiology; Intelligence; Intelligence Tests; Jaundice, Neonatal - epidemiology; Male; Medicine; Medicine & Public Health; Pituitary Neoplasms - epidemiology; Pregnancy; Pregnancy Complications, Neoplastic - epidemiology; Prolactinoma - epidemiology
• ISSN: 1386-341X; 1573-7403
• DOI: 10.1007/s11102-016-0717-2

Purpose To determine the physical status and intelligence scores of children of acromegalic mothers and to compare them with those of children from mothers without acromegaly. Methods Six women with acromegaly who became pregnant under follow-up between 2010 and 2014 and their 16 children (group A) were assessed and compared with 16 children of healthy women (group B) and 15 children of women with prolactinoma (group C). The physical examinations of children were performed by the department of pediatric endocrinology and intelligence quotient (IQ) testing was undertaken by adult and pediatric psychiatry departments, using appropriate scales for their ages. Results Six of the 16 children (girls/boys: 7/9) were born after the diagnosis of acromegaly. Five of the 6 pregnancies occured when the patients were taking somatostatin analogs, none continued taking the drugs during pregnancy. The mean IQ of groups A, B, and C were 106.4 ± 12.5, 105.3 ± 12.5, and 103.2 ± 16.1 respectively ( p  > 0.05). The mean ages, birth percentiles, recent weight and height standard deviation scores were similar between groups ( p  > 0.05). Two siblings from group A and 1 child from group B were large for gestational age at birth. At recent follow-up, two children from group A were found tall for their age and one from group C was short for his age and was placed under the care of pediatric endocrinology clinic. Conclusions Pregnancies in acromegaly seems to be uneventful and the general health status and IQ scores of children from women with and without acromegaly were found similar.