Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study

Patients affected by Charcot-Marie-Tooth (CMT) disease experience an impaired balance. Although the causes of the postural instability are not fully understood, somatosensory system seems to play a key role. Mechanical vibration seems to act on the somatosensory system and to improve its function. T...

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Bibliographic Details
Published in:Journal of neurology 2016-07, Vol.263 (7), p.1434-1441
Main Authors: Pazzaglia, Costanza, Camerota, F., Germanotta, M., Di Sipio, E., Celletti, C., Padua, L.
Format: Article
Language:English
Subjects:
Adult
Aged
Balance
Charcot-Marie-Tooth Disease - complications
Charcot-Marie-Tooth Disease - psychology
Disease
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Muscle Strength
Neurology
Neuroradiology
Neurosciences
Original Communication
Physical Therapy Modalities
Pilot Projects
Postural Balance - physiology
Posture
Quality of Life
Rehabilitation
Sensation Disorders - etiology
Sensation Disorders - rehabilitation
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome
Vibration
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Summary:Patients affected by Charcot-Marie-Tooth (CMT) disease experience an impaired balance. Although the causes of the postural instability are not fully understood, somatosensory system seems to play a key role. Mechanical vibration seems to act on the somatosensory system and to improve its function. The aim of our study was to evaluate the effects of focal mechanical vibration (fMV) on the balance of CMT 1A patients. We enrolled 14 genetically confirmed CMT 1A patients (8 female and 6 male, mean age 492 years, range 32–74, mean duration of disease: 13 years, range 1–30). Patients underwent a 3-day fMV treatment on quadriceps and triceps surae and were evaluated before the treatment as well as 1 week and 1 month after the end of the treatment. The primary outcome measure was the Berg Balance Scale (BBS) and the secondary were the Dynamic Gait Index (DGI), the 6 Min Walking Test (6MWT), the muscular strength of lower limbs, the Quality of Life (QoL) questionnaire and the stabilometric variables. The statistical analysis showed a significant modification of the BBS due to the effect of treatment ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-016-8157-5