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Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study
Patients affected by Charcot-Marie-Tooth (CMT) disease experience an impaired balance. Although the causes of the postural instability are not fully understood, somatosensory system seems to play a key role. Mechanical vibration seems to act on the somatosensory system and to improve its function. T...
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| Published in: | Journal of neurology 2016-07, Vol.263 (7), p.1434-1441 |
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| creator | Pazzaglia, Costanza Camerota, F. Germanotta, M. Di Sipio, E. Celletti, C. Padua, L. |
| description | Patients affected by Charcot-Marie-Tooth (CMT) disease experience an impaired balance. Although the causes of the postural instability are not fully understood, somatosensory system seems to play a key role. Mechanical vibration seems to act on the somatosensory system and to improve its function. The aim of our study was to evaluate the effects of focal mechanical vibration (fMV) on the balance of CMT 1A patients. We enrolled 14 genetically confirmed CMT 1A patients (8 female and 6 male, mean age 492 years, range 32–74, mean duration of disease: 13 years, range 1–30). Patients underwent a 3-day fMV treatment on quadriceps and triceps surae and were evaluated before the treatment as well as 1 week and 1 month after the end of the treatment. The primary outcome measure was the Berg Balance Scale (BBS) and the secondary were the Dynamic Gait Index (DGI), the 6 Min Walking Test (6MWT), the muscular strength of lower limbs, the Quality of Life (QoL) questionnaire and the stabilometric variables. The statistical analysis showed a significant modification of the BBS due to the effect of treatment (
p
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| doi_str_mv | 10.1007/s00415-016-8157-5 |
| format | article |
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p
< 0.05). A significant modification was also found in the DGI (
p
< 0.05). Concerning the stabilometric variables we found significant changes only for the eyes closed condition; in particular, a significant decrease was found in Velocity
ML
(
p
< 0.05) and Sway path length (
p
< 0.05). The fMV treatment applied on lower limbs of CMT 1A patients determined an improvement of balance as detected by the BBS. The concurrent improvement of stabilometric variables in the eyes closed condition only suggests that fMV acts mostly on somatosensory afferences. Further studies are needed to confirm these data on a larger sample of CMT patients.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-016-8157-5</identifier><identifier>PMID: 27177999</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Balance ; Charcot-Marie-Tooth Disease - complications ; Charcot-Marie-Tooth Disease - psychology ; Disease ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Muscle Strength ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Physical Therapy Modalities ; Pilot Projects ; Postural Balance - physiology ; Posture ; Quality of Life ; Rehabilitation ; Sensation Disorders - etiology ; Sensation Disorders - rehabilitation ; Severity of Illness Index ; Statistics, Nonparametric ; Treatment Outcome ; Vibration</subject><ispartof>Journal of neurology, 2016-07, Vol.263 (7), p.1434-1441</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-af650857832fa1b2bbf642cac30a4493b22c083da6a1d935f3dabbed61c2ad793</citedby><cites>FETCH-LOGICAL-c405t-af650857832fa1b2bbf642cac30a4493b22c083da6a1d935f3dabbed61c2ad793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27177999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pazzaglia, Costanza</creatorcontrib><creatorcontrib>Camerota, F.</creatorcontrib><creatorcontrib>Germanotta, M.</creatorcontrib><creatorcontrib>Di Sipio, E.</creatorcontrib><creatorcontrib>Celletti, C.</creatorcontrib><creatorcontrib>Padua, L.</creatorcontrib><title>Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Patients affected by Charcot-Marie-Tooth (CMT) disease experience an impaired balance. Although the causes of the postural instability are not fully understood, somatosensory system seems to play a key role. Mechanical vibration seems to act on the somatosensory system and to improve its function. The aim of our study was to evaluate the effects of focal mechanical vibration (fMV) on the balance of CMT 1A patients. We enrolled 14 genetically confirmed CMT 1A patients (8 female and 6 male, mean age 492 years, range 32–74, mean duration of disease: 13 years, range 1–30). Patients underwent a 3-day fMV treatment on quadriceps and triceps surae and were evaluated before the treatment as well as 1 week and 1 month after the end of the treatment. The primary outcome measure was the Berg Balance Scale (BBS) and the secondary were the Dynamic Gait Index (DGI), the 6 Min Walking Test (6MWT), the muscular strength of lower limbs, the Quality of Life (QoL) questionnaire and the stabilometric variables. The statistical analysis showed a significant modification of the BBS due to the effect of treatment (
p
< 0.05). A significant modification was also found in the DGI (
p
< 0.05). Concerning the stabilometric variables we found significant changes only for the eyes closed condition; in particular, a significant decrease was found in Velocity
ML
(
p
< 0.05) and Sway path length (
p
< 0.05). The fMV treatment applied on lower limbs of CMT 1A patients determined an improvement of balance as detected by the BBS. The concurrent improvement of stabilometric variables in the eyes closed condition only suggests that fMV acts mostly on somatosensory afferences. Further studies are needed to confirm these data on a larger sample of CMT patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Balance</subject><subject>Charcot-Marie-Tooth Disease - complications</subject><subject>Charcot-Marie-Tooth Disease - psychology</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Muscle Strength</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Physical Therapy Modalities</subject><subject>Pilot Projects</subject><subject>Postural Balance - physiology</subject><subject>Posture</subject><subject>Quality of Life</subject><subject>Rehabilitation</subject><subject>Sensation Disorders - etiology</subject><subject>Sensation Disorders - rehabilitation</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Treatment Outcome</subject><subject>Vibration</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkU2LFDEQhoMo7uzqD_AiAS9eopWvTre3ZVhXYcXLem6q04mTobszJumF-fdmmFVEEDwloZ56q8JDyCsO7ziAeZ8BFNcMeMNarg3TT8iGKykYV7p7SjYgFTAttboglznvAaCthefkQhhuTNd1G7K_8T5YtEcaPfXR4kRnZ3e4BEsfwpCwhLjQkhyW2S2F1seAEy7W0bDQ7Q6TjYV9wRQcu4-x7Ci_pmPIDrP7QJEewhQLzWUdjy_IM49Tdi8fzyvy7ePN_fYTu_t6-3l7fcesAl0Y-kZDq00rhUc-iGHwjRJ1RQmoVCcHISy0csQG-dhJ7et1GNzYcCtwNJ28Im_PuYcUf6wul34O2bqpbu3imnveQmukaRT8D8qV0AZERd_8he7jmpb6kRMFDTSq5ZXiZ8qmmHNyvj-kMGM69hz6k7P-7KyvzvqTs17XntePyeswu_F3xy9JFRBnINfS8t2lP0b_M_UnQv6ghQ</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Pazzaglia, Costanza</creator><creator>Camerota, F.</creator><creator>Germanotta, M.</creator><creator>Di Sipio, E.</creator><creator>Celletti, C.</creator><creator>Padua, L.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study</title><author>Pazzaglia, Costanza ; Camerota, F. ; Germanotta, M. ; Di Sipio, E. ; Celletti, C. ; Padua, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-af650857832fa1b2bbf642cac30a4493b22c083da6a1d935f3dabbed61c2ad793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Balance</topic><topic>Charcot-Marie-Tooth Disease - complications</topic><topic>Charcot-Marie-Tooth Disease - psychology</topic><topic>Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Muscle Strength</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Physical Therapy Modalities</topic><topic>Pilot Projects</topic><topic>Postural Balance - physiology</topic><topic>Posture</topic><topic>Quality of Life</topic><topic>Rehabilitation</topic><topic>Sensation Disorders - etiology</topic><topic>Sensation Disorders - rehabilitation</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Treatment Outcome</topic><topic>Vibration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pazzaglia, Costanza</creatorcontrib><creatorcontrib>Camerota, F.</creatorcontrib><creatorcontrib>Germanotta, M.</creatorcontrib><creatorcontrib>Di Sipio, E.</creatorcontrib><creatorcontrib>Celletti, C.</creatorcontrib><creatorcontrib>Padua, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pazzaglia, Costanza</au><au>Camerota, F.</au><au>Germanotta, M.</au><au>Di Sipio, E.</au><au>Celletti, C.</au><au>Padua, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>263</volume><issue>7</issue><spage>1434</spage><epage>1441</epage><pages>1434-1441</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Patients affected by Charcot-Marie-Tooth (CMT) disease experience an impaired balance. Although the causes of the postural instability are not fully understood, somatosensory system seems to play a key role. Mechanical vibration seems to act on the somatosensory system and to improve its function. The aim of our study was to evaluate the effects of focal mechanical vibration (fMV) on the balance of CMT 1A patients. We enrolled 14 genetically confirmed CMT 1A patients (8 female and 6 male, mean age 492 years, range 32–74, mean duration of disease: 13 years, range 1–30). Patients underwent a 3-day fMV treatment on quadriceps and triceps surae and were evaluated before the treatment as well as 1 week and 1 month after the end of the treatment. The primary outcome measure was the Berg Balance Scale (BBS) and the secondary were the Dynamic Gait Index (DGI), the 6 Min Walking Test (6MWT), the muscular strength of lower limbs, the Quality of Life (QoL) questionnaire and the stabilometric variables. The statistical analysis showed a significant modification of the BBS due to the effect of treatment (
p
< 0.05). A significant modification was also found in the DGI (
p
< 0.05). Concerning the stabilometric variables we found significant changes only for the eyes closed condition; in particular, a significant decrease was found in Velocity
ML
(
p
< 0.05) and Sway path length (
p
< 0.05). The fMV treatment applied on lower limbs of CMT 1A patients determined an improvement of balance as detected by the BBS. The concurrent improvement of stabilometric variables in the eyes closed condition only suggests that fMV acts mostly on somatosensory afferences. Further studies are needed to confirm these data on a larger sample of CMT patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27177999</pmid><doi>10.1007/s00415-016-8157-5</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Balance Charcot-Marie-Tooth Disease - complications Charcot-Marie-Tooth Disease - psychology Disease Female Humans Male Medicine Medicine & Public Health Middle Aged Muscle Strength Neurology Neuroradiology Neurosciences Original Communication Physical Therapy Modalities Pilot Projects Postural Balance - physiology Posture Quality of Life Rehabilitation Sensation Disorders - etiology Sensation Disorders - rehabilitation Severity of Illness Index Statistics, Nonparametric Treatment Outcome Vibration |
| title | Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study |
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