Prescribing patterns of non-steroidal anti-inflammatory drugs in chronic kidney disease patients in the South African private sector

Background Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used pharmaceutical agents worldwide. NSAIDs are considered nephrotoxic and should therefore be used with caution or be avoided completely in high risk patients, such as chronic kidney disease (CKD) patients. Objec...

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Bibliographic Details
Published in:International journal of clinical pharmacy 2016-08, Vol.38 (4), p.863-869
Main Authors: Meuwesen, Willem P., du Plessis, Jesslee M., Burger, Johanita R., Lubbe, Martie S., Cockeran, Marike
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Child
Child, Preschool
Chronic illnesses
Drug Utilization - statistics & numerical data
Drug Utilization - trends
Female
Humans
Infant
Internal Medicine
Kidney diseases
Male
Medicine
Medicine & Public Health
Middle Aged
Nonsteroidal anti-inflammatory drugs
Pharmacy
Practice Patterns, Physicians' - statistics & numerical data
Practice Patterns, Physicians' - trends
Prescription drugs
Private sector
Private Sector - trends
Renal Insufficiency, Chronic - drug therapy
Research Article
Retrospective Studies
Sex Factors
South Africa
Young Adult
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Summary:Background Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used pharmaceutical agents worldwide. NSAIDs are considered nephrotoxic and should therefore be used with caution or be avoided completely in high risk patients, such as chronic kidney disease (CKD) patients. Objective This study aimed to investigate the prescribing of NSAIDs in CKD patients in order to generate awareness and improve the outcome of these patients. Setting The study was conducted using medicine claims data in the private health sector of South Africa. Method A descriptive, quantitative study was performed, using retrospective data obtained from a Pharmaceutical Benefit Management company. Data from 1 January 2009 to 31 December 2013 were analysed. The study population consisted of all patients with an ICD-10 code for a CKD (N18), in association with a paid claim for an NSAID. Main outcome measure The stratification of NSAID prescribing volume among the CKD population in terms of gender, age, NSAID type, dosage and prescriber type. Results The prescribing of NSAIDs in CKD patients varied between 26 and 40 % over the 5 year study period. No association between gender and CKD patients who received NSAIDs versus those who did not was found, with p  > 0.05 and Cramer’s V 
ISSN:2210-7703
2210-7711
DOI:10.1007/s11096-016-0298-1