Baduanjin Exercise Prevents post-Myocardial Infarction Left Ventricular Remodeling (BE-PREMIER trial): Design and Rationale of a Pragmatic Randomized Controlled Trial

Background Left ventricular (LV) remodeling following myocardial infarction (MI) is an established prognostic factor for adverse cardiovascular events and the leading cause of heart failure. Empirical observations have suggested that Baduanjin exercise, an important component of traditional Chinese...

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Bibliographic Details
Published in:Cardiovascular drugs and therapy 2016-06, Vol.30 (3), p.315-322
Main Authors: Mao, Shuai, Zhang, Xiaoxuan, Shao, Biying, Hu, Xiyan, Hu, Yanan, Li, Winny, Guo, Liheng, Zhang, Minzhou
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Cardiology
Echocardiography
Exercise Therapy
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - physiopathology
Myocardial Infarction - rehabilitation
Original Article
Qigong
Research Design
Ventricular Function, Left - physiology
Ventricular Remodeling
Young Adult
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Summary:Background Left ventricular (LV) remodeling following myocardial infarction (MI) is an established prognostic factor for adverse cardiovascular events and the leading cause of heart failure. Empirical observations have suggested that Baduanjin exercise, an important component of traditional Chinese Qigong, may exert potential benefits on cardiopulmonary function. However, the impact of a Baduanjin exercise-based cardiac rehabilitation program for patients recovering from a recent MI has yet to be assessed. The aim of this trial is to evaluate the potential role of Baduanjin exercise in preventing the maladaptive progression to adverse LV remodeling in patients post-MI. Methods A total of 110 clinically stable patients following an MI after undergoing successful infarct-related artery reperfusion will be randomly assigned to the Baduanjin exercise group or usual exercise control group. In addition to usual physical activity, participants in the Baduanjin exercise group will participate in a 45 min Baduanjin exercise training session twice a week, for a total of 12 weeks. The primary endpoint will be the percentage change in LV end-diastolic volume index (LVEDVi) assessed using echocardiography from baseline to 6 months. Conclusion The results of this study may provide novel evidence on the efficacy of Baduanjin exercise therapy in post-MI patients in reversing adverse LV remodeling and improving clinical outcome. Trial Registration Clinical Trials.gov: NCT02693795.
ISSN:0920-3206
1573-7241
DOI:10.1007/s10557-016-6660-7