Distribution and Clinical Association of Plasma Soluble ST2 during the Development of Type 2 Diabetes

Highlights • We investigated the dynamic changes of plasma soluble ST2 (sST2) levels during the development of type 2 diabetes. • Elevated sST2 levels were not only associated with metabolic characteristics of diabetes but also with a significantly increased risk of diabetes. • With the prediabetic...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2016-08, Vol.118, p.140-145
Main Authors: Lin, Ya-Hui, Zhang, Rong-Cheng, Hou, Li-Bo, Wang, Kai-Juan, Ye, Zhong-Ni, Huang, Tao, Zhang, Jian, Chen, Xi, Kang, Jin-Suo
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis
Biomarkers - blood
Diabetes Mellitus, Type 2 - blood
Disease Progression
Endocrinology & Metabolism
Female
Humans
Interleukin-1 Receptor-Like 1 Protein - blood
Male
Middle Aged
Prediabetes
Prediabetic State - blood
Risk
sST2
Type 2 diabetes
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Summary:Highlights • We investigated the dynamic changes of plasma soluble ST2 (sST2) levels during the development of type 2 diabetes. • Elevated sST2 levels were not only associated with metabolic characteristics of diabetes but also with a significantly increased risk of diabetes. • With the prediabetic population as a reference group, the patients with sST2 levels in the third and fourth quartiles had a higher risk of having diabetes (odds ratios= 2.31 and 4.00, respectively, P
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2016.06.006