Randomized double-blind comparison of ephedrine and phenylephrine for management of post-spinal hypotension in potential fetal compromise

Highlights • Women undergoing caesarean section for potential fetal compromise were studied. • Post-spinal hypotension was treated with phenylephrine 100 μg or ephedrine 8 mg. • One hundred and six patients were randomized to receive phenylephrine or ephedrine. • Fetal acid-base status and Apgar sco...

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Bibliographic Details
Published in:International journal of obstetric anesthesia 2016-08, Vol.27, p.32-40
Main Authors: Mohta, M, Aggarwal, M, Sethi, A.K, Harisinghani, P, Guleria, K
Format: Article
Language:English
Subjects:
Adult
Anesthesia & Perioperative Care
Anesthesia, Obstetrical - adverse effects
Anesthesia, Spinal - adverse effects
Caesarean section
Double-Blind Method
Ephedrine
Ephedrine - therapeutic use
Female
Fetal compromise
Heart Rate, Fetal - drug effects
Humans
Hydrogen-Ion Concentration
Hypotension - drug therapy
Obstetrics and Gynecology
Phenylephrine
Phenylephrine - therapeutic use
Pregnancy
Prospective Studies
Spinal anaesthesia
Systole - drug effects
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Summary:Highlights • Women undergoing caesarean section for potential fetal compromise were studied. • Post-spinal hypotension was treated with phenylephrine 100 μg or ephedrine 8 mg. • One hundred and six patients were randomized to receive phenylephrine or ephedrine. • Fetal acid-base status and Apgar scores were comparable. • Both vasopressors were equally efficacious to treat post-spinal hypotension.
ISSN:0959-289X
1532-3374
DOI:10.1016/j.ijoa.2016.02.004