Antidepressant-like properties of zinc in rodent forced swim test

The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test. Zinc (ZnSO 4) in a dose of 30 mg/kg and imipramine (30 mg/kg), reduced the immobility time in the forced swim test in both species. Moreover, combined treatment in th...

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Bibliographic Details
Published in:Brain research bulletin 2001-05, Vol.55 (2), p.297-300
Main Authors: Kroczka, Bernadeta, Branski, Piotr, Palucha, Agnieszka, Pilc, Andrzej, Nowak, Gabriel
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - pharmacology
Antidepressive Agents, Tricyclic - pharmacology
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Brain - physiopathology
Depression - drug therapy
Depression - metabolism
Depression - physiopathology
Dose-Response Relationship, Drug
Drug Interactions - physiology
Forced swim test
Imipramine - pharmacology
Locomotor activity
Medical sciences
Mice
Motor Activity - drug effects
Motor Activity - physiology
Neuropharmacology
NMDA receptors
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - metabolism
Stress, Physiological - drug therapy
Stress, Physiological - metabolism
Stress, Physiological - physiopathology
Swimming
Zinc
Zinc - pharmacology
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Summary:The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test. Zinc (ZnSO 4) in a dose of 30 mg/kg and imipramine (30 mg/kg), reduced the immobility time in the forced swim test in both species. Moreover, combined treatment in this test with zinc and imipramine at their ineffective doses (1 and 5 mg/kg, respectively) induced a statistically significant effect in rats. The doses active in the forced swim test reduced (in mice) or did not affect (in rats) locomotor activity. The results obtained indicate that zinc induces an antidepressant-like effect and enhances the effect of imipramine in the forced swim test, suggesting a potential antidepressant activity of zinc in humans.
ISSN:0361-9230
1873-2747
DOI:10.1016/S0361-9230(01)00473-7