Withdrawal from chronic morphine administration causes prolonged enhancement of immobility in rat forced swimming test

Opiate-dependent subjects experience severe depression as one of the subjective symptoms during withdrawal. No experimental work, however, has focused on the ability of opiate-withdrawal to produce depression-like behavior in dependent animal. OBJECTIVES. We therefore investigated whether withdrawal...

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Bibliographic Details
Published in:Psychopharmacologia 2001-09, Vol.157 (2), p.217-220
Main Authors: ANRAKU, Tsuyoshi, IKEGAYA, Yuji, MATSUKI, Norio, NISHIYAMA, Nobuyoshi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Depression - psychology
Drug addictions
Drug Administration Schedule
Drug dependence
Drug toxicity and drugs side effects treatment
Immobilization - physiology
Laboratory animals
Male
Medical sciences
Mental depression
Morphine
Morphine - administration & dosage
Motor Activity - drug effects
Motor Activity - physiology
Narcotics - administration & dosage
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Substance Withdrawal Syndrome - psychology
Swimming - psychology
Swimming behavior
Toxicity: nervous system and muscle
Toxicology
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Summary:Opiate-dependent subjects experience severe depression as one of the subjective symptoms during withdrawal. No experimental work, however, has focused on the ability of opiate-withdrawal to produce depression-like behavior in dependent animal. OBJECTIVES. We therefore investigated whether withdrawal from chronic morphine treatment affects immobility in forced swimming test in rats. Morphine was administered in a dose escalation fashion using doses ranging from 20 to 140 mg/kg twice daily for 14 days, followed by 1-6 days of withdrawal, and their duration of immobility was assessed. After the last morphine treatment. an increase in immobility occurred late on day 3 and persisted to at least day 6 of withdrawal without any change in ambulatory activity. The results suggest that the morphine withdrawal resulted in prolonged enhancement of depression-like behavior in drug-dependent laboratory animals.
ISSN:0033-3158
1432-2072
DOI:10.1007/s002130100793