Quantitative volumetric functional MR imaging: an imaging biomarker of early treatment response in hypo-vascular liver metastasis patients after yttrium-90 transarterial radioembolization

Purpose To evaluate the value of quantitative volumetric functional MR imaging in early assessment of response to yttrium-90-labeled ( 90 Y) transarterial radioembolization (TARE) in patients with hypo-vascular liver metastases. Materials and methods Seventy four metastatic lesions in 14 patients wi...

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Bibliographic Details
Published in:Abdominal imaging 2016-08, Vol.41 (8), p.1495-1504
Main Authors: Zhu, Xiangyu, Sobhani, Fatemeh, Xu, Chunmiao, Pan, Li, Ghasebeh, Mounes Aliyari, Kamel, Ihab R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
Embolization, Therapeutic - methods
Evaluation Studies as Topic
Female
Gastroenterology
Hepatology
Humans
Imaging
Liver - diagnostic imaging
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Radiology
Retrospective Studies
Treatment Outcome
Tumor Burden
Yttrium Radioisotopes - therapeutic use
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Summary:Purpose To evaluate the value of quantitative volumetric functional MR imaging in early assessment of response to yttrium-90-labeled ( 90 Y) transarterial radioembolization (TARE) in patients with hypo-vascular liver metastases. Materials and methods Seventy four metastatic lesions in 14 patients with hypo-vascular liver metastases after TARE were included in this retrospective study. Diffusion and contrast-enhanced MR imaging was performed before and early after treatment. All MR images were analyzed by two experienced radiologists. Response by anatomic metrics (RECIST, mRECIST, EASL) and functional metrics (ADC and arterial and venous enhancement) were reported in targeted and non-targeted lesions. A two-sample paired t test was used to compare the changes after TARE. A p value of
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-016-0694-y