Enantioselective Hydrogenation of Diarylmethanimines for Synthesis of Chiral Diarylmethylamines

An enantioselective hydrogenation of N-substituted diarylmethanimines under mild conditions has been first realized by using an iridium catalyst with a chiral f-spiroPhos ligand. This method provides an efficient access to the asymmetric synthesis of a variety of chiral diarylmethylamines and their...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-08, Vol.81 (15), p.6640-6648
Main Authors: Kong, Duanyang, Li, Meina, Zi, Guofu, Hou, Guohua, He, Yong
Format: Article
Language:English
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Summary:An enantioselective hydrogenation of N-substituted diarylmethanimines under mild conditions has been first realized by using an iridium catalyst with a chiral f-spiroPhos ligand. This method provides an efficient access to the asymmetric synthesis of a variety of chiral diarylmethylamines and their derivatives with excellent enantioselectivities (up to 99.4% ee) and high turnover numbers (TON up to 4000).
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b01273