Catalytically Asymmetric Pd/Norbornene Catalysis: Enantioselective Synthesis of (+)-Rhazinal, (+)-Rhazinilam, and (+)-Kopsiyunnanine C1–3

A catalytically asymmetric palladium/norbornene-catalyzed reaction is reported, where α-aryl tetrahydroquinoline derived phosphoramidite L15 is found to be the optimum ligand. Taking advantage of this transformation, the concise and unified enantioselective syntheses of (+)-rhazinal, (+)-rhazinilam,...

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Bibliographic Details
Published in:Organic letters 2016-08, Vol.18 (15), p.3782-3785
Main Authors: Zhao, Kun, Xu, Shibo, Pan, Chongqing, Sui, Xianwei, Gu, Zhenhua
Format: Article
Language:English
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Summary:A catalytically asymmetric palladium/norbornene-catalyzed reaction is reported, where α-aryl tetrahydroquinoline derived phosphoramidite L15 is found to be the optimum ligand. Taking advantage of this transformation, the concise and unified enantioselective syntheses of (+)-rhazinal, (+)-rhazinilam, and (+)-kopsiyunnanine C1, C2, and C3 are realized.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01790